Meta-Analysis

. 2016 Mar 22;133(12):1189-98.

doi: 10.1161/CIRCULATIONAHA.115.018006. Epub 2016 Feb 12.

Do Self-Management Interventions Work in Patients With Heart Failure? An Individual Patient Data Meta-Analysis

Nini H Jonkman¹, Heleen Westland², Rolf H H Groenwold², Susanna Ågren², Felipe Atienza², Lynda Blue², Pieta W F Bruggink-André de la Porte², Darren A DeWalt², Paul L Hebert², Michele Heisler², Tiny Jaarsma², Gertrudis I J M Kempen², Marcia E Leventhal², Dirk J A Lok², Jan Mårtensson², Javier Muñiz², Haruka Otsu², Frank Peters-Klimm², Michael W Rich², Barbara Riegel², Anna Strömberg², Ross T Tsuyuki², Dirk J van Veldhuisen², Jaap C A Trappenburg², Marieke J Schuurmans², Arno W Hoes²

Affiliations

¹ From Department of Rehabilitation, Nursing Science and Sports (N.H.J., H.W., J.C.A.T., M.J.S.) and Julius Center for Health Sciences and Primary Care (R.H.H.G., A.W.H.), University Medical Center Utrecht, The Netherlands; Departments of Medical and Health Sciences and Department of Cardiothoracic Surgery (S.Å.), Department of Medical and Health Sciences, Division of Nursing Science (S.Å., A.S.), Department of Social and Welfare Studies (T.J.), and Department of Cardiology (A.S.), Linköping University, Sweden; Department of Cardiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain (F.A.); British Heart Foundation, Glasgow, UK (L.B.); Department of Cardiology, Deventer Hospital, The Netherlands (P.W.F.B.-A.d.l.P., D.J.A.L.); Division of General Medicine and Clinical Epidemiology, University of North Carolina, Chapel Hill (D.A.D.); Department of Health Services, University of Washington, Seattle (P.L.H.); Department of Internal Medicine, University of Michigan, Ann Arbor (M.H.); Department of Health Services Research, CAPHRI School for Public Health and Primary Care, Maastricht University, The Netherlands (G.I.J.M.K.); Institute of Nursing Science, University of Basel, Switzerland (M.E.L.); Department of Nursing Science, Jönköping University, Sweden (J. Mårtensson); Instituto Universitario de Ciencias de la Salud, Universidad de A Coruña and INIBIC, A Coruña, Spain (J. Muñiz); Graduate School of Health Sciences, Hirosaki University, Aomori, Japan (H.O.); Department of General Practice and Health Services Research, University Hospital Heidelberg, Germany (F.P.-K.); Cardiovascular Division, Washington University School of Medicine, St. Louis, MO (M.W.R.); School of Nursing, University of Pennsylvania, Philadelphia (B.R.); Division of Cardiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada (R.T.T.); and Department of Cardiology, University Medical Center Groningen, The Netherlands (D.J.v.V.). n.jonkman@umcutrecht.
² From Department of Rehabilitation, Nursing Science and Sports (N.H.J., H.W., J.C.A.T., M.J.S.) and Julius Center for Health Sciences and Primary Care (R.H.H.G., A.W.H.), University Medical Center Utrecht, The Netherlands; Departments of Medical and Health Sciences and Department of Cardiothoracic Surgery (S.Å.), Department of Medical and Health Sciences, Division of Nursing Science (S.Å., A.S.), Department of Social and Welfare Studies (T.J.), and Department of Cardiology (A.S.), Linköping University, Sweden; Department of Cardiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain (F.A.); British Heart Foundation, Glasgow, UK (L.B.); Department of Cardiology, Deventer Hospital, The Netherlands (P.W.F.B.-A.d.l.P., D.J.A.L.); Division of General Medicine and Clinical Epidemiology, University of North Carolina, Chapel Hill (D.A.D.); Department of Health Services, University of Washington, Seattle (P.L.H.); Department of Internal Medicine, University of Michigan, Ann Arbor (M.H.); Department of Health Services Research, CAPHRI School for Public Health and Primary Care, Maastricht University, The Netherlands (G.I.J.M.K.); Institute of Nursing Science, University of Basel, Switzerland (M.E.L.); Department of Nursing Science, Jönköping University, Sweden (J. Mårtensson); Instituto Universitario de Ciencias de la Salud, Universidad de A Coruña and INIBIC, A Coruña, Spain (J. Muñiz); Graduate School of Health Sciences, Hirosaki University, Aomori, Japan (H.O.); Department of General Practice and Health Services Research, University Hospital Heidelberg, Germany (F.P.-K.); Cardiovascular Division, Washington University School of Medicine, St. Louis, MO (M.W.R.); School of Nursing, University of Pennsylvania, Philadelphia (B.R.); Division of Cardiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada (R.T.T.); and Department of Cardiology, University Medical Center Groningen, The Netherlands (D.J.v.V.).

PMID: 26873943
PMCID: PMC5180429
DOI: 10.1161/CIRCULATIONAHA.115.018006

Meta-Analysis

Do Self-Management Interventions Work in Patients With Heart Failure? An Individual Patient Data Meta-Analysis

Nini H Jonkman et al. Circulation. 2016.

. 2016 Mar 22;133(12):1189-98.

doi: 10.1161/CIRCULATIONAHA.115.018006. Epub 2016 Feb 12.

Authors

Affiliations

¹ From Department of Rehabilitation, Nursing Science and Sports (N.H.J., H.W., J.C.A.T., M.J.S.) and Julius Center for Health Sciences and Primary Care (R.H.H.G., A.W.H.), University Medical Center Utrecht, The Netherlands; Departments of Medical and Health Sciences and Department of Cardiothoracic Surgery (S.Å.), Department of Medical and Health Sciences, Division of Nursing Science (S.Å., A.S.), Department of Social and Welfare Studies (T.J.), and Department of Cardiology (A.S.), Linköping University, Sweden; Department of Cardiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain (F.A.); British Heart Foundation, Glasgow, UK (L.B.); Department of Cardiology, Deventer Hospital, The Netherlands (P.W.F.B.-A.d.l.P., D.J.A.L.); Division of General Medicine and Clinical Epidemiology, University of North Carolina, Chapel Hill (D.A.D.); Department of Health Services, University of Washington, Seattle (P.L.H.); Department of Internal Medicine, University of Michigan, Ann Arbor (M.H.); Department of Health Services Research, CAPHRI School for Public Health and Primary Care, Maastricht University, The Netherlands (G.I.J.M.K.); Institute of Nursing Science, University of Basel, Switzerland (M.E.L.); Department of Nursing Science, Jönköping University, Sweden (J. Mårtensson); Instituto Universitario de Ciencias de la Salud, Universidad de A Coruña and INIBIC, A Coruña, Spain (J. Muñiz); Graduate School of Health Sciences, Hirosaki University, Aomori, Japan (H.O.); Department of General Practice and Health Services Research, University Hospital Heidelberg, Germany (F.P.-K.); Cardiovascular Division, Washington University School of Medicine, St. Louis, MO (M.W.R.); School of Nursing, University of Pennsylvania, Philadelphia (B.R.); Division of Cardiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada (R.T.T.); and Department of Cardiology, University Medical Center Groningen, The Netherlands (D.J.v.V.). n.jonkman@umcutrecht.
² From Department of Rehabilitation, Nursing Science and Sports (N.H.J., H.W., J.C.A.T., M.J.S.) and Julius Center for Health Sciences and Primary Care (R.H.H.G., A.W.H.), University Medical Center Utrecht, The Netherlands; Departments of Medical and Health Sciences and Department of Cardiothoracic Surgery (S.Å.), Department of Medical and Health Sciences, Division of Nursing Science (S.Å., A.S.), Department of Social and Welfare Studies (T.J.), and Department of Cardiology (A.S.), Linköping University, Sweden; Department of Cardiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain (F.A.); British Heart Foundation, Glasgow, UK (L.B.); Department of Cardiology, Deventer Hospital, The Netherlands (P.W.F.B.-A.d.l.P., D.J.A.L.); Division of General Medicine and Clinical Epidemiology, University of North Carolina, Chapel Hill (D.A.D.); Department of Health Services, University of Washington, Seattle (P.L.H.); Department of Internal Medicine, University of Michigan, Ann Arbor (M.H.); Department of Health Services Research, CAPHRI School for Public Health and Primary Care, Maastricht University, The Netherlands (G.I.J.M.K.); Institute of Nursing Science, University of Basel, Switzerland (M.E.L.); Department of Nursing Science, Jönköping University, Sweden (J. Mårtensson); Instituto Universitario de Ciencias de la Salud, Universidad de A Coruña and INIBIC, A Coruña, Spain (J. Muñiz); Graduate School of Health Sciences, Hirosaki University, Aomori, Japan (H.O.); Department of General Practice and Health Services Research, University Hospital Heidelberg, Germany (F.P.-K.); Cardiovascular Division, Washington University School of Medicine, St. Louis, MO (M.W.R.); School of Nursing, University of Pennsylvania, Philadelphia (B.R.); Division of Cardiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada (R.T.T.); and Department of Cardiology, University Medical Center Groningen, The Netherlands (D.J.v.V.).

PMID: 26873943
PMCID: PMC5180429
DOI: 10.1161/CIRCULATIONAHA.115.018006

Abstract

Background: Self-management interventions are widely implemented in the care for patients with heart failure (HF). However, trials show inconsistent results, and whether specific patient groups respond differently is unknown. This individual patient data meta-analysis assessed the effectiveness of self-management interventions in patients with HF and whether subgroups of patients respond differently.

Methods and results: A systematic literature search identified randomized trials of self-management interventions. Data from 20 studies, representing 5624 patients, were included and analyzed with the use of mixed-effects models and Cox proportional-hazard models, including interaction terms. Self-management interventions reduced the risk of time to the combined end point of HF-related hospitalization or all-cause death (hazard ratio, 0.80; 95% confidence interval [CI], 0.71-0.89), time to HF-related hospitalization (hazard ratio, 0.80; 95% CI, 0.69-0.92), and improved 12-month HF-related quality of life (standardized mean difference, 0.15; 95% CI, 0.00-0.30). Subgroup analysis revealed a protective effect of self-management on the number of HF-related hospital days in patients <65 years of age (mean, 0.70 versus 5.35 days; interaction P=0.03). Patients without depression did not show an effect of self-management on survival (hazard ratio for all-cause mortality, 0.86; 95% CI, 0.69-1.06), whereas in patients with moderate/severe depression, self-management reduced survival (hazard ratio, 1.39; 95% CI, 1.06-1.83, interaction P=0.01).

Conclusions: This study shows that self-management interventions had a beneficial effect on time to HF-related hospitalization or all-cause death and HF-related hospitalization alone and elicited a small increase in HF-related quality of life. The findings do not endorse limiting self-management interventions to subgroups of patients with HF, but increased mortality in depressed patients warrants caution in applying self-management strategies in these patients.

Keywords: heart failure; meta-analysis; self care.

PubMed Disclaimer

Conflict of interest statement

Disclosures: The other authors have no conflict of interest to declare.

Figures

**Figure 1**
Forest plot of effects of self-management interventions on heart failure-related quality of life, heart failure-related hospitalization, and all-cause mortality. CI indicates confidence interval; HR, hazard ratio; and SMD, standardized mean difference.

See this image and copyright information in PMC

References

1. Ambrosy AP, Fonarow GC, Butler J, Chionel O, Greene SJ, Vaduganathan M, Nodari S, Lam CSP, Sato N, Shah AN, Gheorghiade M. The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries. J Am Coll Cardiol. 2014;63:1123–1133. - PubMed
1. Curtis LH, Greiner MA, Hammill BG, Kramer JM, Whellan DJ, Schulman KA, Hernandez AF. Early and long-term outcomes of heart failure in elderly persons, 2001–2005. Arch Intern Med. 2008;168:2481–2488. - PMC - PubMed
1. Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, Jessup M, Konstam MA, Mancini DM, Michl K, Oates JA, Rahko PS, Silver MA, Stevenson LW, Yancy CW, Antman EM. ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure) Circulation. 2005;112:e154–e235. - PubMed
1. Jovicic A, Holroyd-Leduc JM, Straus SE. Effects of self-management intervention on health outcomes of patients with heart failure: a systematic review of randomized controlled trials. BMC Cardiovasc Disord. 2006;6:43. - PMC - PubMed
1. Ditewig JB, Blok H, Havers J, van Veenendaal H. Effectiveness of self-management interventions on mortality, hospital readmissions, chronic heart failure hospitalization rate and quality of life in patients with chronic heart failure: a systematic review. Patient Educ Couns. 2010;78:297–315. - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

P30 DK092926/DK/NIDDK NIH HHS/United States

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Medical
- ClinicalTrials.gov
- MedlinePlus Health Information
Research Materials
- NCI CPTC Antibody Characterization Program
Miscellaneous
- NCI CPTAC Assay Portal

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Do Self-Management Interventions Work in Patients With Heart Failure? An Individual Patient Data Meta-Analysis

Affiliations

Do Self-Management Interventions Work in Patients With Heart Failure? An Individual Patient Data Meta-Analysis

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Research Materials

Miscellaneous