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Review
. 2016 Mar;17(3):18.
doi: 10.1007/s11934-016-0575-5.

Prostate Cancer Imaging with Novel PET Tracers

Liza Lindenberg  1   2 , Peter Choyke  3   4 , William Dahut  5   6
Affiliations
Review

Prostate Cancer Imaging with Novel PET Tracers

Liza Lindenberg et al. Curr Urol Rep. 2016 Mar.

Abstract

Molecular imaging of prostate cancer is in a dynamic phase of development. Currently approved techniques are limited and researchers have been working on novel agents to improve accuracy in targeting and detecting prostate tumors. In addition, the complexity of various prostate cancer states also contributes to the challenges in evaluating suitable radiotracer candidates. We have highlighted nuclear medicine tracers that focus on mechanisms involved in bone metastasis, prostate cancer cell membrane synthesis, amino acid analogs, androgen analogs, and the prostate specific membrane antigen. Encouraging results with many of these innovative radiotracer compounds will not only advance diagnostic capabilities for prostate cancer but open opportunities for theranostic applications to treat this worldwide malignancy.

Keywords: 11C acetate; 11C/18F choline; 18F DCFBC; 18F DHT; 18F FACBC; 18F NaF; 68Ga PSMA.

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Conflict of interest statement

Conflict of Interest Liza Lindenberg, Peter Choyke, and William Dahut each declare no potential conflicts of interest.

Figures

Fig. 1
Fig. 1
62-year-old patient with high-risk prostate cancer and no evidence of disease outside the prostate by radionuclide bone scan or CT, with PSA 14.06. 18F DCFBC demonstrates focal uptake in left supraclavicular and multiple retroperitoneal lymph nodes highly suggestive for metastatic disease
See this image and copyright information in PMC

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