Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 Mar;41(3):207-209.
doi: 10.1016/j.tibs.2016.01.005. Epub 2016 Feb 11.

Mitochondrial Dysfunction Meets Senescence

Suchira Gallage  1 , Jesús Gil  2
Affiliations
Comment

Mitochondrial Dysfunction Meets Senescence

Suchira Gallage et al. Trends Biochem Sci. 2016 Mar.

Abstract

Cellular senescence and mitochondrial dysfunction are hallmarks of ageing, but until now their relationship has not been clear. Recent work by Wiley et al. shows that mitochondrial defects can cause a distinct senescence phenotype termed MiDAS (mitochondrial dysfunction-associated senescence). MiDAS has a specific secretome that is able to drive some of the aging phenotypes. These findings suggest novel therapeutic opportunities for treating age-related pathologies.

Keywords: SASP; Senescence; Sirtuins; ageing; mitochondria; secretome.

PubMed Disclaimer

Comment on

LinkOut - more resources