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. 2016 Oct;48(4):1420-1428.
doi: 10.4143/crt.2015.309. Epub 2016 Feb 12.

Clinical Practices and Outcomes on Chemotherapy-Induced Nausea and Vomiting Management in South Korea: Comparison with Asia-Pacific Data of the Pan Australasian Chemotherapy Induced Emesis Burden of Illness Study

Myung Ah Lee  1 , Eun Kyung Cho  2 , Sung Yong Oh  3 , Joong Bae Ahn  4 , Ji Yun Lee  5 , Burke Thomas  5 , Hun Jung  5 , Jong Gwang Kim  6
Affiliations

Clinical Practices and Outcomes on Chemotherapy-Induced Nausea and Vomiting Management in South Korea: Comparison with Asia-Pacific Data of the Pan Australasian Chemotherapy Induced Emesis Burden of Illness Study

Myung Ah Lee et al. Cancer Res Treat. 2016 Oct.

Abstract

Purpose: This study reported patient outcomes of chemotherapy-induced nausea and vomiting (CINV) prophylaxis for highly emetogenic chemotherapy (HEC) and moderately emetogenic chemotherapy (MEC) regimens and evaluated its adherence to acute-phase CINV prophylaxis in the Korean population subset of the Pan Australasian Chemotherapy Induced Emesis burden of illness (PrACTICE) study.

Materials and methods: This subgroup analysis evaluated 158 Korean patients receiving HEC or MEC and compared the data (wherever possible) with that of 648 patients from the Asia-Pacific (AP) region. Study endpoints included evaluation of primary CINV prophylaxis and adherence to acute-phase CINV prophylaxis in cycle 1 (American Society of Clinical Oncology [ASCO] Quality Oncology Practice Initiative [QOPI]).

Results: In South Korea and the AP, a 5-hydroxytryptamine-3 receptor antagonist (5HT3-RA) prophylaxis for the acute phase was administered to 79/80 patients (98.8%) for HEC and 70/71 patients (98.6%) for MEC regimens (QOPI-1). Triple regimen (corticosteroid-5HT3-RA-neurokinin 1-RA) was initiated in 46/80 patients (57.5%) for prophylaxis of acute CINV in cycle 1 of HEC (QOPI-3). Double regimen (corticosteroid-5HT3-RA, with or within NK1-RA) was initiated in 61/71 patients (83.1%) for control of acute CINV in cycle 1 of MEC a(QOPI-2).

Conclusion: Active management of CINV is necessary in cycle 1 of HEC in South Korea, despite higher rates than the AP region. Adherence to the international guidelines for CINV prophylaxis requires attention in the acute phase in cycle 1 of the HEC regimen.

Keywords: Antiemetics; Drug therapy; Nausea; Vomiting.

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Conflict of interest statement

This study was funded by Merck & Co., Inc. Medical writing services were provided by Dr. Annirudha Chillar of Cactus Communications and funded by Merck & Co., Inc. The authors retained full control of the manuscript content.

Figures

Fig. 1.
Fig. 1.
Distribution of enrolled patients in PrACTICE (CONSORT flow diagram). PrACTICE, Pan Australasian Chemotherapy Induced Emesis burden of illness.
See this image and copyright information in PMC

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