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. 2016 Feb 10;21(2):209.
doi: 10.3390/molecules21020209.

Chemical Characterization and Trypanocidal, Leishmanicidal and Cytotoxicity Potential of Lantana camara L. (Verbenaceae) Essential Oil

Luiz Marivando Barros  1   2 , Antonia Eliene Duarte  3   4 , Maria Flaviana Bezerra Morais-Braga  5 , Emily Pansera Waczuk  6 , Celeste Vega  7 , Nadghia Figueiredo Leite  8 , Irwin Rose Alencar de Menezes  9 , Henrique Douglas Melo Coutinho  10 , João Batista Teixeira Rocha  11 , Jean Paul Kamdem  12   13
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Chemical Characterization and Trypanocidal, Leishmanicidal and Cytotoxicity Potential of Lantana camara L. (Verbenaceae) Essential Oil

Luiz Marivando Barros et al. Molecules. .

Abstract

Drug resistance in the treatment of neglected parasitic diseases, such as leishmaniasis and trypanosomiasis, has led to the search and development of alternative drugs from plant origins. In this context, the essential oil extracted by hydro-distillation from Lantana camara leaves was tested against Leishmania braziliensis and Trypanosoma cruzi. The results demonstrated that L. camara essential oil inhibited T. cruzi and L. braziliensis with IC50 of 201.94 μg/mL and 72.31 μg/mL, respectively. L. camara essential oil was found to be toxic to NCTC929 fibroblasts at 500 μg/mL (IC50 = 301.42 μg/mL). The composition of L. camara essential oil analyzed by gas chromatography-mass spectrometry (GC/MS) revealed large amounts of (E)-caryophyllene (23.75%), biciclogermacrene (15.80%), germacrene D (11.73%), terpinolene (6.1%), and sabinene (5.92%), which might be, at least in part, responsible for its activity. Taken together, our results suggest that L. camara essential oil may be an important source of therapeutic agents for the development of alternative drugs against parasitic diseases.

Keywords: Lantana camara; Leishmania braziliensis; Trypanosoma cruzi; essential oil.

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Conflict of interest statement

The authors declare no conflict of interest.

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