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. 2015;31(12):1267-1275.
Epub 2015 Dec 23.

Mechanism and Function of Angiogenin in Hematopoietic Malignancy

Kevin A Goncalves  1 , Guo-Fu Hu  1
Affiliations

Mechanism and Function of Angiogenin in Hematopoietic Malignancy

Kevin A Goncalves et al. Zhongguo Sheng Wu Hua Xue Yu Fen Zi Sheng Wu Xue Bao. 2015.

Abstract

Angiogenic factors have been widely implicated in the formation and progression of solid tumors. A number of angiogenic mediators have been recently appreciated as having equivalent function in non-solid tumors, such as leukemia. One such factor, angiogenin (ANG), promotes tumor cell growth and angiogenesis in solid cancers; however its precise function(s) in hematological disorders are not fully understood. This review summarizes current knowledge of the function and therapeutic potential of angiogenic factors, with particular emphasis on the role and hypothesized mechanism of ANG in a non-solid tumor setting.

Keywords: RNA processing; angiogenesis; angiogenin; bone marrow diseases; cancer; cell proliferation; leukemia; malignant hematopoiesis.

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