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Review
. 2016 Feb 14;22(6):2046-59.
doi: 10.3748/wjg.v22.i6.2046.

Glucose metabolism in gastric cancer: The cutting-edge

Lian-Wen Yuan  1 , Hiroharu Yamashita  1 , Yasuyuki Seto  1
Affiliations
Review

Glucose metabolism in gastric cancer: The cutting-edge

Lian-Wen Yuan et al. World J Gastroenterol. .

Abstract

Glucose metabolism in gastric cancer cells differs from that of normal epithelial cells. Upregulated aerobic glycolysis (Warburg effect) in gastric cancer meeting the demands of cell proliferation is associated with genetic mutations, epigenetic modification and proteomic alteration. Understanding the mechanisms of aerobic glycolysis may contribute to our knowledge of gastric carcinogenesis. Metabolomic studies offer novel, convenient and practical tools in the search for new biomarkers for early detection, diagnosis, prognosis, and chemosensitivity prediction of gastric cancer. Interfering with the process of glycolysis in cancer cells may provide a new and promising therapeutic strategy for gastric cancer. In this article, we present a brief review of recent studies of glucose metabolism in gastric cancer, with primary focus on the clinical applications of new biomarkers and their potential therapeutic role in gastric cancer.

Keywords: Biomarker; Gastric cancer; Glucose metabolism; Metabolomics; Therapy; Warburg effect.

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Figures

Figure 1
Figure 1
Glucose metabolism in gastric cancer. The figure incorporates the interplay between glucose and the other three metabolic pathways[110].
Figure 2
Figure 2
Targeting hexokinase II as a potential mechanism to inhibit the Warburg effect in cancer cells[135].
See this image and copyright information in PMC

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