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. 2016 Jan;28(84):23-9.

Effects of Hyperbilirubinemia on Auditory Brainstem Response of Neonates Treated with Phototherapy

Negin Salehi  1 , Fereshte Bagheri  1 , Hamid Ramezani Farkhani  1
Affiliations

Effects of Hyperbilirubinemia on Auditory Brainstem Response of Neonates Treated with Phototherapy

Negin Salehi et al. Iran J Otorhinolaryngol. 2016 Jan.

Abstract

Introduction: One of the most common pathologies in neonates is hyperbilirubinemia, which is a good marker for damage to the central nervous system. The sensitivity of the auditory system to bilirubin has been previously documented, with much discrepancy in its effects on Auditory Brainstem Response results. Thus the objective of this study was to evaluate the effects of hyperbilirubinemia on Auditory Brainstem Response of neonates treated with phototherapy.

Materials and methods: Forty-two term neonates with hyperbilirubinemia, who underwent phototherapy participated in this cross sectional study. The recording of Auditory Brainstem Response was made shortly after confirming that the total serum bilirubin level was greater than 15 µg/dl. Latency of waves I, III, V and inter-peak latencies of the waves were measured. To test the hypothesis about the difference of means between the two groups, continuous variables were compared using either the t-test (normal distribution) or the Mann-Whitney test (non-normal distribution).

Results: There was a significant increase in the absolute latencies of waves III and V, and I-III and I-V inter-peak latencies of the sample group compared to the control group in both ears (P<0.05). However, wave I absolute latency and III-V inter-peak interval did not show a significant difference between the two study groups (P>0.05).

Conclusion: The results of this study underline the importance of the Auditory Brainstem Response Test as an efficient tool for monitoring the auditory brainstem pathway in neonates who are at risk of neurotoxicity and for diagnosing the earliest stages of auditory damage caused by high levels of bilirubin.

Keywords: Auditory Brainstem Response; Hyperbilirubinemia; neonate; total serum bilirubin.

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References

    1. de Steuben C. Breast-feeding and jaundice: a review. Journal of nurse-midwifery. 1992;37(2):S59–S66. - PubMed
    1. Gubernick JA, Rosenberg HK, Ilaslan H, Kessler A. US Approach to Jaundice in Infants and Children 1. Radiographics. 2000;20(1):173–95. - PubMed
    1. Fay DL, Schellhase KG, Suresh GK. Bilirubin screening for normal newborns: a critique of the hour-specific bilirubin nomogram. Pediatrics. 2009;124(4):1203–5. - PubMed
    1. Protocol A. ABM Clinical Protocol# 22: Guidelines for Management of Jaundice in the Breastfeeding Infant Equal to or Greater Than 35 Weeks’ Gestation. Breastfeeding Medicine. 2010;5(2):87–93. - PubMed
    1. Bhutani VK, Maisels MJ, Stark AR, Buonocore G. Management of jaundice and prevention of severe neonatal hyperbilirubinemia in infants≥ 35 weeks gestation. Neonatology. 2008;94(1):63–7. - PubMed

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