Persistent organic pollutants and pregnancy complications

Melissa M Smarr¹, Katherine L Grantz², Cuilin Zhang³, Rajeshwari Sundaram⁴, José M Maisog⁵, Dana Boyd Barr⁶, Germaine M Buck Louis⁷

Affiliations

¹ Office of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd., Rockville, MD 20852, USA.. Electronic address: melissa.smarr@mail.nih.gov.
² Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd., Rockville, MD 20852, USA.. Electronic address: katherine.grantz@nih.gov.
³ Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd., Rockville, MD 20852, USA.. Electronic address: zhangcu@mail.nih.gov.
⁴ Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd., Rockville, MD 20852, USA.. Electronic address: sundaramr2@mail.nih.gov.
⁵ Glotech, Inc., Rockville, MD 20852, USA. Electronic address: bravas02@gmail.com.
⁶ Department of Environmental Health, Rollins School of Public Health, Emory University, 1518 Clifton Rd, Atlanta, GA 30322, USA. Electronic address: dbbarr@emory.edu.
⁷ Office of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd., Rockville, MD 20852, USA.. Electronic address: louisg@mail.nih.gov.

PMID: 26878640
PMCID: PMC7751424
DOI: 10.1016/j.scitotenv.2016.02.030

Persistent organic pollutants and pregnancy complications

Melissa M Smarr et al. Sci Total Environ. 2016.

. 2016 May 1:551-552:285-91.

doi: 10.1016/j.scitotenv.2016.02.030. Epub 2016 Feb 12.

Authors

Melissa M Smarr¹, Katherine L Grantz², Cuilin Zhang³, Rajeshwari Sundaram⁴, José M Maisog⁵, Dana Boyd Barr⁶, Germaine M Buck Louis⁷

Affiliations

¹ Office of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd., Rockville, MD 20852, USA.. Electronic address: melissa.smarr@mail.nih.gov.
² Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd., Rockville, MD 20852, USA.. Electronic address: katherine.grantz@nih.gov.
³ Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd., Rockville, MD 20852, USA.. Electronic address: zhangcu@mail.nih.gov.
⁴ Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd., Rockville, MD 20852, USA.. Electronic address: sundaramr2@mail.nih.gov.
⁵ Glotech, Inc., Rockville, MD 20852, USA. Electronic address: bravas02@gmail.com.
⁶ Department of Environmental Health, Rollins School of Public Health, Emory University, 1518 Clifton Rd, Atlanta, GA 30322, USA. Electronic address: dbbarr@emory.edu.
⁷ Office of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd., Rockville, MD 20852, USA.. Electronic address: louisg@mail.nih.gov.

PMID: 26878640
PMCID: PMC7751424
DOI: 10.1016/j.scitotenv.2016.02.030

Abstract

We sought to investigate the relationship between maternal preconception exposures to persistent organic pollutants (POPs) and pregnancy complications, gestational diabetes (GDM) and gestational hypertension. Data from 258 (51%) women with human chorionic gonadotropin (hCG) confirmed pregnancies reaching ≥24weeks gestation, from a prospective cohort of 501 couples who discontinued contraception to attempt pregnancy, were analyzed. Preconception concentrations of 9 organochlorine pesticides (OCPs) and 10 polybrominated diphenyl ethers (PBDEs) were quantified in serum. In separate multiple logistic regression models of self-reported physician diagnosed outcomes: GDM (11%) and gestational hypertension (10%), chemicals were natural log-transformed and rescaled by their standard deviation (SD). Models were adjusted for serum lipids, and then adjusted for age, body mass index, race, and smoking. Models were additionally adjusted for the sum of the remaining POPs in each chemical class. Women's serum concentration of PBDE congener 153 (PBDE-153) was positively associated with an increased odds of GDM per SD increase in log-transformed concentration, for unadjusted (OR=1.36, 95%CI: 1.02-1.81), a priori adjusted (OR=1.38, 95% CI: 1.03-1.86) and with the sum of remaining PBDEs (OR=1.79, 95% CI: 1.18, 2.74) models. Our findings suggest that at environmentally relevant concentrations, maternal exposure to POPs prior to conception may contribute to increased chance of developing GDM.

Keywords: Gestational diabetes mellitus; Hypertension; Organochlorine pesticides; Polybrominated diphenyl ethers; Preconception.

Published by Elsevier B.V.

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References

1. Akins JR, Waldrep K, Bernert JT Jr, 1989. The estimation of total serum lipids by a completely enzymatic ‘summation’ method. Clin. Chim. Acta 184, 219–226. - PubMed
1. American College of Obstetricians and Gynecologists, 2001. ACOG Practice Bulletin. Clinical management guidelines for obstetrician-gynecologists. Number 30, September 2001 (replaces Technical Bulletin Number 200, December 1994). Gestational diabetes. Obstet. Gynecol 98, 525–538. - PubMed
1. American College of Obstetricians and Gynecologists, 2002. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American College of Obstetricians and Gynecologists. International Journal of Gynaecology and Obstetrics: The Official Organ of the International Federation of Gynaecology and Obstetrics 77, 67–75. - PubMed
1. American Diabetes Association, 2004. Gestational diabetes mellitus. Diabetes Care 27 (Suppl. 1), S88–S90. - PubMed
1. Arrebola JP, Gonzalez-Jimenez A, Fornieles-Gonzalez C, Artacho-Cordon F, Olea N, Escobar-Jimenez F, Fernandez-Soto ML, 2015. Relationship between serum concentrations of persistent organic pollutants and markers of insulin resistance in a cohort of women with a history of gestational diabetes mellitus. Environ. Res 136, 435–440. - PubMed

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Persistent organic pollutants and pregnancy complications

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Persistent organic pollutants and pregnancy complications

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