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. 2016 Feb 16:6:19868.
doi: 10.1038/srep19868.

Associations of Plasma FGF2 Levels and Polymorphisms in the FGF2 Gene with Obesity Phenotypes in Han Chinese Population

Ruo-Han Hao  1 , Yan Guo  1 , Shan-Shan Dong  1 , Gai-Zhi Weng  2 , Han Yan  1 , Dong-Li Zhu  1 , Xiao-Feng Chen  1 , Jia-Bin Chen  1 , Tie-Lin Yang  1
Affiliations

Associations of Plasma FGF2 Levels and Polymorphisms in the FGF2 Gene with Obesity Phenotypes in Han Chinese Population

Ruo-Han Hao et al. Sci Rep. .

Abstract

Obesity is highly heritable, but the specific genes influencing obesity related traits are largely unknown. Fibroblast growth factor 2 (FGF2) could influence adipocyte differentiation. However, the association of FGF2 polymorphisms and obesity remains unclear. This study aimed to investigate the associations of both the plasma FGF2 levels and SNPs in FGF2 gene with obesity phenotypes in Han Chinese populations. Plasma FGF2 levels were measured and subjected to association analyses in 62 subjects. Eleven SNPs in FGF2 were genotyped and tested for associations in a discovery sample of 1,300 subjects. SNPs significantly associated with obesity were subjected to replication in another independent sample of 1,035 subjects. We found that plasma FGF2 levels were positively correlated with fat mass (P = 0.010). Association analyses in the discovery sample identified three SNPs (rs1449683, rs167428, rs308442) significantly associated with fat mass after multiple testing adjustments (P < 0.0045). Subsequent replication study successfully validated one SNP (rs167428) associated with fat mass (P(combine) = 3.46 × 10(-5)). eQTL analyses revealed that SNPs associated with obesity also affected FGF2 expression. Our findings suggested that high plasma FGF2 level correlated with increased risk of obesity, and FGF2 gene polymorphisms could affect individual variances of obesity in Han Chinese population.

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Figures

Figure 1
Figure 1. Correlation plots of plasma levels of FGF2 after adjusting for sex and age with
(a) fat mass and (b) BMI.
Figure 2
Figure 2. Linkage disequilibrium (LD) blocks and haplotype frequencies for FGF2 in the discovery sample.
(a) LD blocks are marked with triangles. Squares color scheme represents the value of r2, and the black color indicates strong LD. (b) Haplotypes in the three blocks across FGF2. The haplotype frequencies are shown to the right of each haplotype. The SNP numbers correspond to those in Table 2.
See this image and copyright information in PMC

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