Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Feb 16:9:103.
doi: 10.1186/s13104-016-1881-1.

Salivary profile in diabetic patients: biochemical and immunological evaluation

Monica Virginia Viegas Lima-Aragão  1 , João de Jesus de Oliveira-Junior  2 , Márcia Cristina Gonçalves Maciel  3 , Lucilene Amorim Silva  4 , Flávia Raquel Fernandes do Nascimento  5 , Rosane Nassar Meireles Guerra  6
Affiliations

Salivary profile in diabetic patients: biochemical and immunological evaluation

Monica Virginia Viegas Lima-Aragão et al. BMC Res Notes. .

Abstract

Background: The aim of this study was to evaluate the biochemical and immunological characteristics of saliva from diabetic patients compared to non-diabetic adults.

Methods: Eighty-eight diabetic adults and 39 non-diabetic adults (control) were included in the study. Glucose, urea, calcium, total protein and amylase were determined by a colorimetric method. The levels of secretory IgA and the IgA anti-Streptococcus mutans and anti-insulin IgA antibodies were measured by enzyme-linked immunosorbent assay (ELISA). Caries status was evaluated using the DMFT index.

Results: Glucose, urea, calcium, anti-S. mutans IgA, total IgA, and anti-insulin IgA were significantly higher in diabetic patients, whereas total protein and amylase levels were lower in these patients. There was no positive correlation between blood and salivary glucose levels in either group. Diabetic patients had a higher DMFT index.

Conclusions: The present study showed for the first time that IgA levels in diabetic patients'saliva, shows correlation with systemic biochemical parameters. Thus the saliva is an useful tool to follow the systemic health status in these patients.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Salivary concentration of total IgA, anti-mutans (Streptococcus mutans) IgA and anti-insulin IgA in diabetic patients and healthy controls. The results are reported as the mean ± standard deviation (X ± SD) of 88 diabetic patients and 39 controls. (*) Significant when p < 0.05 compared to the control group
See this image and copyright information in PMC

References

    1. Wild S, Roglick G, Green A, Sicree R, King H. Global prevalence of diabetics: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047–1053. doi: 10.2337/diacare.27.5.1047. - DOI - PubMed
    1. American Diabetes Association Standards of medical care in diabetes. Diabetes Care. 2012;35(Suppl 1):S11–S63. - PMC - PubMed
    1. Moura SAB, Medeiros AMC, Costa FRH, Moraes PH, Oliveira filho SA. Valor diagnóstico da saliva em doenças orais e sistêmicas: uma revisão da literatura. Pesq Bras Odontop Clin Integr. 2007;7:187–194. doi: 10.4034/1519.0501.2007.0072.0014. - DOI
    1. Bigler LR, Streckfus CF, Dubinsky WP. Salivary biomarkers for detection of malignant tumors that are remote from oral cavity. Clin Lab Med. 2009;29:71–85. doi: 10.1016/j.cll.2009.01.004. - DOI - PubMed
    1. Oliveira Júnior JJ Guerra RNM. Biomarcadores imunológicos da saliva. RevCiencSaude (São Luís) 2010;12:136–145.

Publication types

MeSH terms