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Review
. 2016 Apr;14(2):54-65.
doi: 10.1007/s11914-016-0302-7.

Osteoporosis Associated with Epilepsy and the Use of Anti-Epileptics-a Review

Sandra J Petty  1   2   3   4   5   6   7 , Helen Wilding  8 , John D Wark  9   10
Affiliations
Free article
Review

Osteoporosis Associated with Epilepsy and the Use of Anti-Epileptics-a Review

Sandra J Petty et al. Curr Osteoporos Rep. 2016 Apr.
Free article

Abstract

The increased rate of fractures associated with epilepsy has been long recognised but remains incompletely understood. Study quality and study results have varied, with some but not all studies showing bone diseases including osteoporosis and/or osteomalacia, and a high prevalence of vitamin D insufficiency and deficiency are also noted. Falls risk can also be higher in patients with epilepsy taking anti-epileptic medications, potentially leading to fracture. Larger research collaborations are recommended to further advance understanding in this field, particularly to examine underlying genetic and pharmacogenomic associations of epilepsy and anti-epileptic medication usage and its association with bone diseases and fractures, as well as further investigation into optimal management of bone health in epilepsy.

Keywords: Anti-epileptic medication; Epilepsy; Fracture risk; Osteoporosis.

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References

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