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Multicenter Study
. 2016 May;42(5):817-828.
doi: 10.1007/s00134-015-4206-2. Epub 2016 Feb 15.

The Intensive Care Global Study on Severe Acute Respiratory Infection (IC-GLOSSARI): a multicenter, multinational, 14-day inception cohort study

Yasser Sakr  1 , Ricard Ferrer  2 , Konrad Reinhart  3 , Richard Beale  4 , Andrew Rhodes  5 , Rui Moreno  6 , Jean Francois Timsit  7 , Laurent Brochard  8   9 , B Taylor Thompson  10   11 , Ederlon Rezende  12 , Jean Daniel Chiche  13   14   15 ; IC-GLOSSARI Investigators; ESICM Trials Group
Affiliations
Multicenter Study

The Intensive Care Global Study on Severe Acute Respiratory Infection (IC-GLOSSARI): a multicenter, multinational, 14-day inception cohort study

Yasser Sakr et al. Intensive Care Med. 2016 May.

Erratum in

Abstract

Purpose: In this prospective, multicenter, 14-day inception cohort study, we investigated the epidemiology, patterns of infections, and outcome in patients admitted to the intensive care unit (ICU) as a result of severe acute respiratory infections (SARIs).

Methods: All patients admitted to one of 206 participating ICUs during two study weeks, one in November 2013 and the other in January 2014, were screened. SARI was defined as possible, probable, or microbiologically confirmed respiratory tract infection with recent onset dyspnea and/or fever. The primary outcome parameter was in-hospital mortality within 60 days of admission to the ICU.

Results: Among the 5550 patients admitted during the study periods, 663 (11.9 %) had SARI. On admission to the ICU, Gram-positive and Gram-negative bacteria were found in 29.6 and 26.2 % of SARI patients but rarely atypical bacteria (1.0 %); viruses were present in 7.7 % of patients. Organ failure occurred in 74.7 % of patients in the ICU, mostly respiratory (53.8 %), cardiovascular (44.5 %), and renal (44.6 %). ICU and in-hospital mortality rates in patients with SARI were 20.2 and 27.2 %, respectively. In multivariable analysis, older age, greater severity scores at ICU admission, and hematologic malignancy or liver disease were independently associated with an increased risk of in-hospital death, whereas influenza vaccination prior to ICU admission and adequate antibiotic administration on ICU admission were associated with a lower risk.

Conclusions: Admission to the ICU for SARI is common and associated with high morbidity and mortality rates. We identified several risk factors for in-hospital death that may be useful for risk stratification in these patients.

Keywords: Intensive care; Outcome; Pneumonia; Severe acute respiratory infections.

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Conflict of interest statement

The authors declare that they do not have any conflict of interest in relation to the subject of this manuscript.

Figures

Fig. 1
Fig. 1
Flowchart of recruitment to and inclusion in the study. ICU intensive care unit, SARI severe acute respiratory infection
Fig. 2
Fig. 2
Microbiological isolates according to mode of acquisition of severe acute respiratory infection (SARI). *p < 0.05
See this image and copyright information in PMC

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