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Review
. 2016 Mar:112:1-9.
doi: 10.1016/j.rmed.2016.01.022. Epub 2016 Feb 1.

The potential of methylxanthine-based therapies in pediatric respiratory tract diseases

Ainhoa Oñatibia-Astibia  1 , Eva Martínez-Pinilla  2 , Rafael Franco  3
Affiliations
Free article
Review

The potential of methylxanthine-based therapies in pediatric respiratory tract diseases

Ainhoa Oñatibia-Astibia et al. Respir Med. 2016 Mar.
Free article

Abstract

Caffeine, theophylline and theobromine are the most known methylxanthines as they are present in coffee, tea and/or chocolate. In the last decades, a huge experimental effort has been devoted to get insight into the variety of actions that these compounds exert in humans. From such knowledge it is known that methylxanthines have a great potential in prevention, therapy and/or management of a variety of diseases. The benefits of methylxanthine-based therapies in the apnea of prematurity and their translational potential in pediatric affections of the respiratory tract are here presented.

Keywords: Airways; Apnea of prematurity; Asthma; Caffeine; Cough; Theobromine; Theophylline; Xanthine.

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