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. 2016 Mar;89(3):721-3.
doi: 10.1016/j.kint.2015.10.019.

Adriamycin susceptibility among C57BL/6 substrains

Ehtesham Arif  1 , Ashish K Solanki  1 , Deepak Nihalani  2
Affiliations

Adriamycin susceptibility among C57BL/6 substrains

Ehtesham Arif et al. Kidney Int. 2016 Mar.
No abstract available

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Figures

Figure 1
Figure 1. C57BL/6N mice are susceptible to adriamycin-induced injury
Adriamycin or saline was retro-orbitally injected in anesthetized C57BL/6N mice (n = 6–8) (15 mg/kg of body weight). Urine from each mouse was collected at 1-week intervals, and the 4-week urine samples were analyzed by sodium dodecylsulfate–polyacrylamide gel electrophoresis followed by Coomassie blue staining and enzyme-linked immunosorbent assay to calculate albumin-creatinine ratios. Albuminuria was noted only in adriamycin-injected mice (a and b; *P < 0.05). Scanning and transmission electron microscopy analysis of kidney tissues from these mice further confirms podocyte damage in adriamycin-injected mice only (c and d). BSA, bovine serum albumin.
See this image and copyright information in PMC

References

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