Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Jul 6;274(5666):62-3.
doi: 10.1038/274062a0.

Specific insulin binding site on T and B lymphocytes as a marker of cell activation

J H Helderman, T B Strom

Specific insulin binding site on T and B lymphocytes as a marker of cell activation

J H Helderman et al. Nature. .
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
A representative binding isotherm (a) and binding competition curve (b) for insulin on lymphocytes from Lewis rats 7 d after receiving (Lewis × Brown Norway) F1 skin allografts. The half maximal equilibrium constant, calculated from the concentration of insulin at which binding is half-maximal, was 1.3 nM. The affinity of unlabelled insulin for its binding site is estimated from the concentration dependence of the binding inhibition curve and was 0.2 nM. Both values permit binding at physiological concentrations of insulin.
See this image and copyright information in PMC

References

    1. Freychet P, Roth J, Neville DM., Jr Proc natn Acad Sci USA. 1971;68:1833–1837. - PMC - PubMed
    1. Cuatrecasas P. J biol Chem. 1971;246:6532–6542. - PubMed
    1. Cuatrecasas P. Proc natn Acad Sci USA. 1972;69:1277–1281. - PMC - PubMed
    1. Olefsky J, Bacon VS, Baur S. Metabolism. 1976;25:179–191. - PubMed
    1. Forgue ME, Freychet P. Diabetes. 1975;24:715–723. - PubMed

Publication types