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. 2016 Mar 11;52(20):3959-61.
doi: 10.1039/c6cc01014h. Epub 2016 Feb 16.

A simple aptamer-functionalized gold nanorods based biosensor for the sensitive detection of MCF-7 breast cancer cells

Yuan Li  1 , Yulong Zhang, Man Zhao, Qianqian Zhou, Lili Wang, Huizhong Wang, Xiaohui Wang, Linsheng Zhan
Affiliations

A simple aptamer-functionalized gold nanorods based biosensor for the sensitive detection of MCF-7 breast cancer cells

Yuan Li et al. Chem Commun (Camb). .

Abstract

Herein, we describe a novel approach for the rapid diagnosis of human breast carcinoma MCF-7 cells with a detection limit of 100 cells mL(-1). In our strategy, the MCF-7 cells are specially recognized by mucin 1 protein (MUC-1) aptamer-functionalized gold nanorods (GNRs) through specific interactions, whose signals are simply read out by its unique localized surface plasmon resonance (LSPR) spectra.

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