Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. II. Ophthalmic Disease

Sahar Kohanim¹, Sotiria Palioura², Hajirah N Saeed³, Esen K Akpek⁴, Guillermo Amescua², Sayan Basu⁵, Preston H Blomquist⁶, Charles S Bouchard⁷, John K Dart⁸, Xiaowu Gai³, José A P Gomes⁹, Darren G Gregory¹⁰, Geetha Iyer¹¹, Deborah S Jacobs¹², Anthony J Johnson¹³, Shigeru Kinoshita¹⁴, Iason S Mantagos¹⁵, Jodhbir S Mehta¹⁶, Victor L Perez², Stephen C Pflugfelder¹⁷, Virender S Sangwan⁵, Kimberly C Sippel¹⁸, Chie Sotozono¹⁴, Bhaskar Srinivasan¹¹, Donald T H Tan¹⁶, Radhika Tandon¹⁹, Scheffer C G Tseng²⁰, Mayumi Ueta¹⁴, James Chodosh²¹

Affiliations

¹ Vanderbilt Eye Institute, Vanderbilt University School of Medicine, USA.
² Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, USA.
³ Massachusetts Eye and Ear Infirmary, Harvard Medical School, USA.
⁴ The Wilmer Eye Institute, Johns Hopkins University School of Medicine, USA.
⁵ LV Prasad Eye Institute, India.
⁶ University of Texas Southwestern Medical Center, USA.
⁷ Loyola University Chicago, USA.
⁸ Moorfields Eye Hospital, NHS Foundation Trust, UK.
⁹ Federal University of São Paulo, Brazil.
¹⁰ Rocky Mountain Lions Eye Institute, University of Colorado School of Medicine, USA.
¹¹ Dr G Sitalakshmi Memorial Clinic for Ocular Surface Disorders, Sankara Nethralaya, India.
¹² Massachusetts Eye and Ear Infirmary, Harvard Medical School, USA; Boston Foundation for Sight, USA.
¹³ United States Army Institute of Surgical Research, USA.
¹⁴ Kyoto Prefectural University of Medicine, Japan.
¹⁵ Boston Children's Hospital, Harvard Medical School, USA.
¹⁶ Singapore National Eye Centre, Singapore Eye Research Institute, Singapore.
¹⁷ Cullen Eye Institute, Baylor College of Medicine, USA.
¹⁸ Weill Cornell Medical College, USA.
¹⁹ Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, India.
²⁰ Ocular Surface Center, Ocular Surface Research & Education Foundation, USA.
²¹ Massachusetts Eye and Ear Infirmary, Harvard Medical School, USA. Electronic address: James_Chodosh@meei.harvard.edu.

PMID: 26882981
DOI: 10.1016/j.jtos.2016.02.001

Review

Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. II. Ophthalmic Disease

Sahar Kohanim et al. Ocul Surf. 2016 Apr.

. 2016 Apr;14(2):168-88.

doi: 10.1016/j.jtos.2016.02.001. Epub 2016 Feb 13.

Authors

Affiliations

¹ Vanderbilt Eye Institute, Vanderbilt University School of Medicine, USA.
² Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, USA.
³ Massachusetts Eye and Ear Infirmary, Harvard Medical School, USA.
⁴ The Wilmer Eye Institute, Johns Hopkins University School of Medicine, USA.
⁵ LV Prasad Eye Institute, India.
⁶ University of Texas Southwestern Medical Center, USA.
⁷ Loyola University Chicago, USA.
⁸ Moorfields Eye Hospital, NHS Foundation Trust, UK.
⁹ Federal University of São Paulo, Brazil.
¹⁰ Rocky Mountain Lions Eye Institute, University of Colorado School of Medicine, USA.
¹¹ Dr G Sitalakshmi Memorial Clinic for Ocular Surface Disorders, Sankara Nethralaya, India.
¹² Massachusetts Eye and Ear Infirmary, Harvard Medical School, USA; Boston Foundation for Sight, USA.
¹³ United States Army Institute of Surgical Research, USA.
¹⁴ Kyoto Prefectural University of Medicine, Japan.
¹⁵ Boston Children's Hospital, Harvard Medical School, USA.
¹⁶ Singapore National Eye Centre, Singapore Eye Research Institute, Singapore.
¹⁷ Cullen Eye Institute, Baylor College of Medicine, USA.
¹⁸ Weill Cornell Medical College, USA.
¹⁹ Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, India.
²⁰ Ocular Surface Center, Ocular Surface Research & Education Foundation, USA.
²¹ Massachusetts Eye and Ear Infirmary, Harvard Medical School, USA. Electronic address: James_Chodosh@meei.harvard.edu.

PMID: 26882981
DOI: 10.1016/j.jtos.2016.02.001

Abstract

Our purpose is to comprehensively review the state of the art with regard to Stevens- Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), with particular attention to improving the management of associated ocular surface complications. SJS and TEN are two ends of a spectrum of immune-mediated disease, characterized in the acute phase by a febrile illness followed by skin and mucous membrane necrosis and detachment. Part I of this review focused on the systemic aspects of SJS/TEN and was published in the January 2016 issue of this journal. The purpose of Part II is to summarize the ocular manifestations and their management through all phases of SJS/TEN, from acute to chronic. We hope this effort will assist ophthalmologists in their management of SJS/TEN, so that patients with this complex and debilitating disease receive the best possible care and experience the most optimal outcomes in their vision and quality of life.

Keywords: Stevens-Johnson Syndrome; amniotic membrane transplantation; apoptosis; drug-induced disease; immune-mediated disease; keratinocyte death; keratoprosthesis; ocular surface reconstruction; toxic epidermal necrolysis.

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Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. II. Ophthalmic Disease

Affiliations

Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. II. Ophthalmic Disease

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