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Review
. 2016 Apr;29(2):53-7.
doi: 10.1007/s13577-016-0134-x. Epub 2016 Feb 16.

Hematopoietic stem cells: multiparameter regulation

Kedong Song  1 , Liying Li  2 , Yiwei Wang  3 , Tianqing Liu  2
Affiliations
Review

Hematopoietic stem cells: multiparameter regulation

Kedong Song et al. Hum Cell. 2016 Apr.

Abstract

Hematopoietic stem cells (HSCs) are capable to self-renew with multi-potency which generated much excitement in clinical therapy. However, the main obstacle of HSCs in clinical application was insufficient number of HSCs which were derived from either bone marrow, peripheral blood or umbilical cord blood. This review briefly discusses the indispensable utility of growth factors and cytokines, stromal cells, extracellular matrix, bionic scaffold and microenvironment aiming to control the hematopoiesis in all directions and provide a better and comprehensive understanding for in vitro expansion of hematopoietic stem cells.

Keywords: Ex vivo expansion; Hematopoietic stem cells (HSCs); Multiparameter regulation.

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