Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Nov;41(7):614-624.
doi: 10.1007/s00059-016-4401-0. Epub 2016 Feb 16.

[Impact of guideline adherence on mortality in treatment of left heart failure]

[Article in German]
Affiliations

[Impact of guideline adherence on mortality in treatment of left heart failure]

[Article in German]
S Neubauer et al. Herz. 2016 Nov.

Abstract

Background: The German national guidelines on chronic heart failure provide treatment recommendations to physicians and reflect the current level of evidence; however, it is questionable to what extent these recommendations are applied in the routine practice and what the effect of guideline adherence on mortality is.

Methods: In this study the claims data of a major German health insurance fund collected over a period of 4 years were analyzed. Using binary logistic regression and Cox regression analyses the influence of drug prescriptions, diagnostic measures, influenza vaccination, the New York Heart Association (NYHA) status, the age and gender on mortality were examined.

Results: The study population consisted of 85,465 heart failure patients. Approximately 60 % of the drugs were prescribed according to the guidelines. There was a positive correlation between a higher NYHA status and mortality with an odds ratio (OR) of 3.264. Especially pharmacotherapy with angiotensin-converting enzyme (ACE) inhibitors and beta blockers according to the guidelines was associated with a lower mortality rate (OR 0.448 resp. 0.444). Also patients diagnosed using echocardiography at regular intervals showed a lower risk of dying (OR 0.314).

Conclusion: The results of this large sample could confirm the results of clinical trials that a therapy according to the guidelines has a significant impact on mortality. By analyzing the claims data evidence was found that in the treatment of heart failure patients the medical results could be improved by adherence to guideline recommendations.

Keywords: Claims data; Guideline adherence; Heart failure; Mortality; Pharmacotherapy.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Congest Heart Fail. 2009 Nov-Dec;15(6):256-64 - PubMed
    1. J Heart Lung Transplant. 2012 Oct;31(10):1052-64 - PubMed
    1. Circulation. 2012 Jul 24;126(4):501-6 - PubMed
    1. Eur Heart J. 2005 Aug;26(16):1653-9 - PubMed
    1. JAMA Intern Med. 2013 Mar 25;173(6):468-70 - PubMed

MeSH terms

Substances

LinkOut - more resources