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. 2015 Nov 15;8(11):21080-8.
eCollection 2015.

Characteristics of bacterial vaginosis infection in cervical lesions with high risk human papillomavirus infection

Huan Lu  1 , Peng-Cheng Jiang  2 , Xiao-Dan Zhang  3 , Wen-Jing Hou  1 , Zhen-Hong Wei  1 , Jia-Qi Lu  4 , Hao Zhang  4 , Guang-Xu Xu  1 , Yuan-Ping Chen  1 , Yuan Ren  5 , Li Wang  6 , Rong Zhang  1 , Ying Han  1
Affiliations

Characteristics of bacterial vaginosis infection in cervical lesions with high risk human papillomavirus infection

Huan Lu et al. Int J Clin Exp Med. .

Abstract

High risk human papillomavirus (HPV) infection is the major cause of cervical cancer. Bacterial vaginosis (BV) is considered as the most prevalent vaginal imbalance affecting women of reproductive age. However, the relationship between HPV and BV infection is unclear. This study aimed to assess the prevalence of human papillomavirus (HPV) infection combined with bacterial vaginosis (BV) infection in Shanghai suburbs and evaluate associations between bacterial vaginosis with HPV infection, cervical intraepithelial neoplasia (CIN) and cervical cancer.

Methods: From October 1, 2009 to October 31, 2013, a total number of 3502 women who visited Fengxian Hospital, Southern Medical University were enrolled in this study. All participants gave informed consent and agreed to HPV, BV, chlamydia, mycoplasma and thinprepcytologic test (TCT). In addition, all women took histopathologic examination under colposcopy. Statistical analyses were done using SPSS 17.0 for windows (IBM). In present study the overall BV-positive rate was 9.25%. The top three high risk HPV types were listed as follows (in descending order): HPV16, 52, 58. Moreover, our data showed BV infection tended to occur in the HPV positive women, HPV infection also tended to occur in the BV positive women. Most of the women who present HPV with BV infection were younger than 30 years old. We also found that CIN and cervical cancer occurred mainly in HPV/BV positive and HPV with BV positive group. BV infection and HPV infection may haveconsistency or synergies. HPV with BV infection may increase the incidence of CIN and cervical cancer.

Keywords: Bacterial vaginosis infection; HPV types; cervical lesion.

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Figures

Figure 1
Figure 1
Distributions of HPV types in BV infection. A. Distributions of HPV types with BV negative in different age. B. Distributions of HPV types with BV positive in different age.
Figure 2
Figure 2
Distributions of HPV types in different cervical lesions. A. Distribution of HPV types with BV negative in different cervical lesions. B. Distributions of HPV types with BV positive in different cervical lesions.
See this image and copyright information in PMC

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