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. 2015 Dec 15;8(12):22167-74.
eCollection 2015.

Association of risk of non-Hodgkin's lymphoma with hepatitis B virus infection: a meta-analysis

Zhenjia Qi  1 , Hao Wang  2 , Guangxun Gao  3
Affiliations

Association of risk of non-Hodgkin's lymphoma with hepatitis B virus infection: a meta-analysis

Zhenjia Qi et al. Int J Clin Exp Med. .

Abstract

Objective: A meta-analysis was carried out to systematically evaluate the correlation between hepatitis B virus (hepatitis B virus, HBV) infection and risk of non-Hodgkin's lymphoma (non-Hodgkin lymphoma, NHL).

Methods: We searched Medline, EMBASE, PubMed, Cochrane Library, Chinese Biomedical Literature Database, Chinese Journal Full-text Database, Chinese scientific journals full text databases and collected information about HBV infection and risk of NHL associated case-control studies. Two reviewers extracted useful information which were included in the study independently, and Revman 5.2 was used for meta-analysis.

Results: A total of 24 studies were included in this research. Meta-analysis showed that among all of the included studies the heterogeneity were existed (I(2) = 76%, P<0.05). With random effects model the OR was 2.39 (95% CI, 1.93-3.96), indicating infection rate in NHL patients with HBV was higher than that in the control group. Subgroup analysis according to ethnicity suggested that HBV infection were associated with NHL risk both in Asian (OR = 2.46, 95% CI: 2.01, 3.00, P<0.001) and Caucasian (OR = 2.15, 95% CI: 1.37, 3.37, P<0.001) population.

Conclusion: HBV infection may increase the risk of NHL, but it still need a large number of experiments and epidemiological studies to verify.

Keywords: Hepatitis B virus; Non-Hodgkin’s lymphoma; meta-analysis; risk.

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Figures

Figure 1
Figure 1
The flow chart of literature identified.
Figure 2
Figure 2
Forest plot of the relation between HBV infection and NHL risk in total population.
Figure 3
Figure 3
Forest plot of the relation between HBV infection and NHL risk in Asian population.
Figure 4
Figure 4
Forest plot of the relation between HBV infection and NHL risk in Caucasian population.
Figure 5
Figure 5
Funnel plot for publication bias tests.
See this image and copyright information in PMC

References

    1. Rapti I, Hadziyannis S. Risk for hepatocellular carcinoma in the course of chronic hepatitis B virus infection and the protective effect of therapy with nucleos(t)ide analogues. World J Hepatol. 2015;7:1064–73. - PMC - PubMed
    1. Weinbaum CM, Williams I, Mast EE, Wang SA, Finelli L, Wasley A, Neitzel SM, Ward JW Centers for Disease Control and Prevention (CDC) Recommendations for identification and public health management of persons with chronic hepatitis B virus infection. MMWR Recomm Rep. 2008;57:1–20. - PubMed
    1. Persico E, De Renzo A, La Mura V, Bruno S, Masarone M, Torella R, Persico M. Occult hepatitis B virus infection in patients with non-Hodgkin lymphoma: The need for early diagnosis in anti-Hbv positive patients. Gut. 2007;56:1470–1471. - PMC - PubMed
    1. Yang G, Han M, Chen F, Xu Y, Chen E, Wang X, Liu Y, Sun J, Hou J, Ning Q, Wang Z. Hepatitis B virus genotype B and mutations in basal core promoter and pre-core/core genes associated with acute-on-chronic liver failure: a multicenter cross-sectional study in China. Hepatol Int. 2014;8:508–516. - PubMed
    1. Martin P, Lau DT, Nguyen MH, Janssen HL, Dieterich DT, Peters MG, Jacobson IM. A Treatment Algorithm for the Management of Chronic Hepatitis B Virus Infection in the United States: 2015 Update. Clin Gastroenterol Hepatol. 2015;13:2071–2087. e16. - PubMed

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