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Observational Study
. 2016 Mar;106(3):194-200.
doi: 10.5935/abc.20160024. Epub 2016 Feb 16.

The Relationship between GRACE Score and Epicardial Fat Thickness in non-STEMI Patients

[Article in English, Portuguese]
Ilker Gul  1 , Mustafa Zungur  1 , Ahmet Cagri Aykan  2 , Teyyar Gokdeniz  3 , Ezgi Kalaycioğlu  2 , Turhan Turan  2 , Engin Hatem  4 , Faruk Boyaci  5
Affiliations
Observational Study

The Relationship between GRACE Score and Epicardial Fat Thickness in non-STEMI Patients

[Article in English, Portuguese]
Ilker Gul et al. Arq Bras Cardiol. 2016 Mar.

Abstract

Background: GRACE risk score (GS) is a scoring system which has a prognostic significance in patients with non-ST segment elevation myocardial infarction (non-STEMI).

Objective: The present study aimed to determine whether end-systolic or end-diastolic epicardial fat thickness (EFT) is more closely associated with high-risk non-STEMI patients according to the GS.

Methods: We evaluated 207 patients who had non-STEMI beginning from October 2012 to February 2013, and 162 of them were included in the study (115 males, mean age: 66.6 ± 12.8 years). End-systolic and end-diastolic EFTs were measured with echocardiographic methods. Patients with high in-hospital GS were categorized as the H-GS group (in hospital GS > 140), while other patients were categorized as the low-to-moderate risk group (LM-GS).

Results: Systolic and diastolic blood pressures of H-GS patients were lower than those of LM-GS patients, and the average heart rate was higher in this group. End-systolic EFT and end-diastolic EFT were significantly higher in the H-GS group. The echocardiographic assessment of right and left ventricles showed significantly decreased ejection fraction in both ventricles in the H-GS group. The highest correlation was found between GS and end-diastolic EFT (r = 0.438).

Conclusion: End-systolic and end-diastolic EFTs were found to be increased in the H-GS group. However, end-diastolic EFT and GS had better correlation than end-systolic EFT and GS.

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Conflict of interest statement

Potential Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1
Receiver operating characteristic (ROC) curve.The end-systolic epicardial fat thickness cut-off value which predicts the H-GS group was calculated as 0.765 cm (AUC: 0.699; 95% CI: 0.613-0.785; sensitivity: 67%; specificity: 64%). End-diastolic epicardial fat thickness cut-off value was found to be 0.468 cm for the H-GS group (AUC: 0.709; 95% CI: 0.621-0.797; sensitivity: 68%; specificity: 72%). (AUC: Area Under the Curve; CI: Confidence Interval; H-GS: High GRACE score).
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