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. 2016 Aug;37(8):10909-15.
doi: 10.1007/s13277-016-4934-0. Epub 2016 Feb 17.

Fascin 1 promoted the growth and migration of non-small cell lung cancer cells by activating YAP/TEAD signaling

Zhigang Liang  1   2 , Ying Wang  1 , Zhenya Shen  3 , Xiaomei Teng  1 , Xinjian Li  2 , Chenwei Li  2 , Weijie Wu  2 , Zenghui Zhou  2 , Zishan Wang  2
Affiliations
Free article

Fascin 1 promoted the growth and migration of non-small cell lung cancer cells by activating YAP/TEAD signaling

Zhigang Liang et al. Tumour Biol. 2016 Aug.
Free article

Abstract

Fascin 1 (Fascin actin-bundling protein 1) is an actin-binding protein. Although several studies have reported the dysregulation of Fascin 1 in non-small cell lung cancer (NSCLC), its functions in the progression of NSCLC and the related molecular mechanism were not fully understood. In this study, the expression of Fascin 1 in NSCLC tissues was determined using quantitative PCR (qPCR), and the roles of Fascin 1 in the progression of NSCLC were investigated. It was found that both the messenger RNA (mRNA) level and the protein level of Fascin 1 were upregulated in NSCLC tissues. Forced expression of Fascin 1 promoted the growth and migration of NSCLC cells, while knocking down the expression of Fascin 1 inhibited the growth, migration, and tumorigenesis of NSCLC cells. Mechanism studies showed that Fascin 1 increased the transcriptional activity of the YAP/TEAD (Yes-associated protein/TEA domain transcriptional factor) complex, and knocking down the expression of Fascin 1 attenuated the expression of target genes downstream the YAP/TEAD complex. In addition, MST1 interacted with Fascin 1. Taken together, Fascin 1 plays an oncogenic role in NSCLC by activating the transcriptional activity of the YAP/TEAD complex.

Keywords: Cell growth; Fascin 1; Migration; NSCLC; YAP/TEAD signaling.

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References

    1. Nat Rev Mol Cell Biol. 2012 Sep;13(9):591-600 - PubMed
    1. J Environ Pathol Toxicol Oncol. 2015;34(3):201-12 - PubMed
    1. Pathol Int. 2012 Dec;62(12):777-84 - PubMed
    1. J Antibiot (Tokyo). 2006 Nov;59(11):685-92 - PubMed
    1. J Cell Sci. 2005 Nov 15;118(Pt 22):5393-403 - PubMed

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