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. 2016 Jan;11(1):154-156.
doi: 10.3892/etm.2015.2863. Epub 2015 Nov 12.

Clinical significance of plasma levels of brain natriuretic peptide and cardiac troponin T in patients with sepsis

Jifeng Wang  1 , Wenli Ji  1 , Zhengqin Xu  1 , Tao Pan  1
Affiliations

Clinical significance of plasma levels of brain natriuretic peptide and cardiac troponin T in patients with sepsis

Jifeng Wang et al. Exp Ther Med. 2016 Jan.

Abstract

Sepsis is a systemic inflammatory response of the body to an antigen and can become a life-threatening condition by triggering a cascade of changes leading to multiple organ failure such as heart failure. The aim of the present study was to examine the changes of the plasma levels of N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in patients with sepsis and to analyze their prognostic significance. A total of 38 hospitalized patients with sepsis were included in the present study. The patients were divided into the survival and death groups, based on their prognosis. The plasma levels of NT-proBNP and cTnT for the two groups were measured for all the patients on the 1st, 3rd and 7th day of admission. The plasma levels of NT-proBNP and cTnT between the two groups were compared and their association with prognosis were analyzed. The plasma levels of NT-proBNP and cTnT in the death group were significantly higher than those in the survival group (P<0.05). Additionally, a positive assocciation of the plasma levels of NT-proBNP and cTnT was identified (P<0.05). In conclusion, the plasma levels of NT-proBNP and cTnT may be used as routine clinical biomarkers to assess the prognosis of patients with sepsis.

Keywords: N-terminal of the prohormone brain natriuretic peptide; cardiac troponin T; sepsis.

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References

    1. Bentzer P, Russell JA, Walley KR. Advances in sepsis research. Clin Chest Med. 2015;36:521–530. doi: 10.1016/j.ccm.2015.05.009. - DOI - PubMed
    1. Guidelines for treatment of severe sepsis/septic shock in China. Crit Care Med. 2015;6:401–426. (In Chinese)
    1. Kübler A, Adamik B, Ciszewicz-Adamiczka B, Ostrowska E. Severe sepsis in intensive care units in Poland - a point prevalence study in 2012 and 2013. Anaesthesiol Intensive Ther. 2015;47:315–319. doi: 10.5603/AIT.2015.0047. - DOI - PubMed
    1. Zhang D, Li H, Li J. The change of cardiac troponin I on patients with sepsis and septic shock as well as its clinical significance. J Pract Med. 2011;27:49–51.
    1. Wang X, Wei S, Li T. The application of coagulation-fibrinolysis dynamic graph on the detection of sepsis coagulation fibrinolytic imbalances. Chongqing Med J. 2008;37:1706–1708.

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