Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Dec 19;5(1):e29005.
doi: 10.5812/cardiovascmed.29005. eCollection 2016 Feb.

Comparison of Gated SPECT Myocardial Perfusion Imaging with Echocardiography for the Measurement of Left Ventricular Volumes and Ejection Fraction in Patients With Severe Heart Failure

Maryam Shojaeifard  1 , Tahereh Ghaedian  2 , Nahid Yaghoobi  3 , Hadi Malek  3 , Hasan Firoozabadi  3 , Ahmad Bitarafan-Rajabi  3 , Majid Haghjoo  4 , Ahmad Amin  5 , Nasrin Azizian  4 , Feridoon Rastgou  3
Affiliations

Comparison of Gated SPECT Myocardial Perfusion Imaging with Echocardiography for the Measurement of Left Ventricular Volumes and Ejection Fraction in Patients With Severe Heart Failure

Maryam Shojaeifard et al. Res Cardiovasc Med. .

Abstract

Background: Gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is known as a feasible tool for the measurement of left ventricular ejection fraction (EF) and volumes, which are of great importance in the management and follow-up of patients with coronary artery diseases. However, considering the technical shortcomings of SPECT in the presence of perfusion defect, the accuracy of this method in heart failure patients is still controversial.

Objectives: The aim of the present study was to compare the results from gated SPECT MPI with those from echocardiography in heart failure patients to compare echocardiographically-derived left ventricular dimension and function data to those from gated SPECT MPI in heart failure patients.

Patients and methods: Forty-one patients with severely reduced left ventricular systolic function (EF ≤ 35%) who were referred for gated SPECT MPI were prospectively enrolled. Quantification of EF, end-diastolic volume (EDV), and end-systolic volume (ESV) was performed by using quantitative gated spect (QGS) (QGS, version 0.4, May 2009) and emory cardiac toolbox (ECTb) (ECTb, revision 1.0, copyright 2007) software packages. EF, EDV, and ESV were also measured with two-dimensional echocardiography within 3 days after MPI.

Results: A good correlation was found between echocardiographically-derived EF, EDV, and ESV and the values derived using QGS (r = 0.67, r = 0.78, and r = 0.80 for EF, EDV, and ESV, respectively; P < 0.001) and ECTb (r = 0.68, 0.79, and r = 0.80 for EF, EDV, and ESV, respectively; P < 0.001). However, Bland-Altman plots indicated significantly different mean values for EF, 11.4 and 20.9 using QGS and ECTb, respectively, as compared with echocardiography. ECTb-derived EDV was also significantly higher than the EDV measured with echocardiography and QGS. The highest correlation between echocardiography and gated SPECT MPI was found for mean values of ESV different.

Conclusions: Gated SPECT MPI has a good correlation with echocardiography for the measurement of left ventricular EF, EDV, and ESV in patients with severe heart failure. However, the absolute values of these functional parameters from echocardiography and gated SPECT MPI measured with different software packages should not be used interchangeably.

Keywords: Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography; Echocardiography; Left Ventricular.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.. Bland-Altman Plots for EF (a), EDV (b), and ESV (c) Measured by Using QGS and Echocardiography
(QGS, Quantitative Gated SPECT; EF, ejection fraction; EDV, end-diastolic volume; ESV, end-systolic volume).
Figure 2.
Figure 2.. Bland-Altman Plots for EF (a), EDV (b), and ESV (c) Measured by using ECTb and Echocardiography
(ECTb, Emory Cardiac Toolbox; EF, ejection fraction; EDV, end-diastolic volume; ESV, end-systolic volume).
Figure 3.
Figure 3.. Bland-Altman Plots for EF (a), EDV (b), and ESV (c) Measured by Using ECTb and QGS
(ECTb, Emory Cardiac Toolbox; QGS, Quantitative Gated SPECT; EF, ejection fraction; EDV, end-diastolic volume; ESV, end-systolic volume).
Figure 4.
Figure 4.. Regression Lines With 95% Confidence Interval and Regression Equations for the Estimation of ECTb-Derived EF (a), EDV (b), and ESV (c) From Corresponding Variables by Using QGS Software
(ECTb, Emory Cardiac Toolbox; QGS, Quantitative Gated SPECT; EF, ejection fraction; EDV, end-diastolic volume; ESV, end-systolic volume).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, et al. 2009 Focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the International Society for Heart and Lung Transplantation. J Am Coll Cardiol. 2009;53(15):e1–e90. doi: 10.1016/j.jacc.2008.11.013. - DOI - PubMed
    1. Oh JK, Velazquez EJ, Menicanti L, Pohost GM, Bonow RO, Lin G, et al. Influence of baseline left ventricular function on the clinical outcome of surgical ventricular reconstruction in patients with ischaemic cardiomyopathy. Eur Heart J. 2013;34(1):39–47. doi: 10.1093/eurheartj/ehs021. - DOI - PMC - PubMed
    1. Patel MR, White RD, Abbara S, Bluemke DA, Herfkens RJ, Picard M, et al. 2013 ACCF/ACR/ASE/ASNC/SCCT/SCMR appropriate utilization of cardiovascular imaging in heart failure: a joint report of the American College of Radiology Appropriateness Criteria Committee and the American College of Cardiology Foundation Appropriate Use Criteria Task Force. J Am Coll Cardiol. 2013;61(21):2207–31. doi: 10.1016/j.jacc.2013.02.005. - DOI - PubMed
    1. Abidov A, Germano G, Hachamovitch R, Slomka P, Berman DS. Gated SPECT in assessment of regional and global left ventricular function: an update. J Nucl Cardiol. 2013;20(6):1118–43. doi: 10.1007/s12350-013-9792-1. - DOI - PubMed
    1. Nichols K, Lefkowitz D, Faber T, Folks R, Cooke D, Garcia EV, et al. Echocardiographic validation of gated SPECT ventricular function measurements. J Nucl Med. 2000;41(8):1308–14. - PubMed

LinkOut - more resources