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. 2016 Apr;106(4):686-8.
doi: 10.2105/AJPH.2016.303061. Epub 2016 Feb 18.

Increasing Benzodiazepine Prescriptions and Overdose Mortality in the United States, 1996-2013

Marcus A Bachhuber  1 , Sean Hennessy  1 , Chinazo O Cunningham  1 , Joanna L Starrels  1
Affiliations

Increasing Benzodiazepine Prescriptions and Overdose Mortality in the United States, 1996-2013

Marcus A Bachhuber et al. Am J Public Health. 2016 Apr.

Abstract

Objectives: To describe trends in benzodiazepine prescriptions and overdose mortality involving benzodiazepines among US adults.

Methods: We examined data from the Medical Expenditure Panel Survey and multiple-cause-of-death data from the Centers for Disease Control and Prevention.

Results: Between 1996 and 2013, the percentage of adults filling a benzodiazepine prescription increased from 4.1% (95% confidence interval [CI] = 3.8%, 4.5%) to 5.6% (95% CI = 5.2%, 6.1%), with an annual percent change of 2.5% (95% CI = 2.1%, 3.0%). The quantity of benzodiazepines filled increased from 1.1 (95% CI = 0.9, 1.2) to 3.6 (95% CI = 3.0, 4.2) kilogram lorazepam equivalents per 100 000 adults (annual percent change = 9.0%; 95% CI = 7.6%, 10.3%). The overdose death rate increased from 0.58 (95% CI = 0.55, 0.62) to 3.07 (95% CI = 2.99, 3.14) per 100 000 adults, with a plateau seen after 2010.

Conclusions: Benzodiazepine prescriptions and overdose mortality have increased considerably. Fatal overdoses involving benzodiazepines have plateaued overall; however, no evidence of decreases was found in any group. Interventions to reduce the use of benzodiazepines or improve their safety are needed.

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Figures

FIGURE 1—
FIGURE 1—
Number of Adults Filling a Benzodiazepine Prescription, Quantity Filled, and Overdose Deaths Involving Benzodiazepines: United States, 1996–2013
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References

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