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Case Reports
. 2016 Mar;27(2):450-2.
doi: 10.1097/SCS.0000000000002423.

Craniosynostosis Following Fetal Methotrexate Exposure

Christopher S Zarella  1 , Frank P Albino, Albert K Oh, Benjamin C Wood, Chima O Oluigbo, John S Myseros, Suresh N Magge, Robert F Keating, Gary F Rogers
Affiliations
Case Reports

Craniosynostosis Following Fetal Methotrexate Exposure

Christopher S Zarella et al. J Craniofac Surg. 2016 Mar.

Abstract

Methotrexate (MTX) is an antimetabolite, folic acid antagonist that inhibits purine nucleotide production, DNA synthesis, and cellular proliferation. Despite widespread therapeutic uses, MTX remains a potent teratogen. Methotrexate embryopathy encompasses multiorgan system dysfunction, including intrauterine growth restriction as well as cardiac, craniofacial, renal, genital, and skeletal abnormalities. Effects of MTX exposure on fetal development continue to be described. This series of 4 patients with MTX-associated craniosynostosis represents the largest published association between prenatal MTX exposure and premature cranial suture closure.

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