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. 2016 Mar;22(3):518-21.
doi: 10.3201/eid2203.151130.

Preliminary Favorable Outcome for Medically and Surgically Managed Extensively Drug-Resistant Tuberculosis, France, 2009-2014

Benoît Henry, Matthieu Revest, Nathalie Dournon, Loïc Epelboin, Guillaume Mellon, Guillaume Bellaud, Pierre Mordant, Damien Le Dû, Nicolas Véziris, Christine Bernard, Sébastien Morel, Stéphane Jauréguiberry, Christian Michelet, Françcois Bricaire, Pierre Tattevin, Éric Caumes

Preliminary Favorable Outcome for Medically and Surgically Managed Extensively Drug-Resistant Tuberculosis, France, 2009-2014

Benoît Henry et al. Emerg Infect Dis. 2016 Mar.

Abstract

We report 20 cases of extensively drug-resistant tuberculosis managed in France. Treatment was individualized and included bedaquiline and linezolid for most patients and surgery in 8 patients. At last follow-up (22 months), 19 patients had achieved conversion from positive to negative on culture testing. These promising results of comprehensive management obtained in a small series deserve confirmation.

Keywords: France; MDR TB; TB; XDR TB; antimicrobial resistance; bacteria; bedaquiline; extensively drug-resistant tuberculosis; multidrug-resistant tuberculosis; outcome; thoracic surgery; tuberculosis; tuberculosis and other mycobacteria.

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