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Clinical Trial
. 2016 Sep;20(9):1863-82.
doi: 10.1007/s10461-015-1270-0.

HPTN 068: A Randomized Control Trial of a Conditional Cash Transfer to Reduce HIV Infection in Young Women in South Africa-Study Design and Baseline Results

Audrey Pettifor  1   2   3   4 , Catherine MacPhail  5   6   7 , Amanda Selin  8 , F Xavier Gómez-Olivé  5 , Molly Rosenberg  9 , Ryan G Wagner  5 , Wonderful Mabuza  5 , James P Hughes  10   11 , Chirayath Suchindran  8   12 , Estelle Piwowar-Manning  13 , Jing Wang  10 , Rhian Twine  5 , Tamu Daniel  8 , Philip Andrew  14 , Oliver Laeyendecker  15   16 , Yaw Agyei  13 , Stephen Tollman  5   17   18 , Kathleen Kahn  5   17   18 ; HPTN 068 protocol team
Affiliations
Clinical Trial

HPTN 068: A Randomized Control Trial of a Conditional Cash Transfer to Reduce HIV Infection in Young Women in South Africa-Study Design and Baseline Results

Audrey Pettifor et al. AIDS Behav. 2016 Sep.

Abstract

Young women in South Africa are at high risk for HIV infection. Cash transfers offer promise to reduce HIV risk. We present the design and baseline results from HPTN 068, a phase III, individually randomized trial to assess the effect of a conditional cash transfer on HIV acquisition among South African young women. A total of 2533 young women were randomized to receive a monthly cash transfer conditional on school attendance or to a control group. A number of individual-, partner-, household- and school-level factors were associated with HIV and HSV-2 infection. After adjusting for age, all levels were associated with an increased odds of HIV infection with partner-level factors conveying the strongest association (aOR 3.05 95 % CI 1.84-5.06). Interventions like cash transfers that address structural factors such as schooling and poverty have the potential to reduce HIV risk in young women in South Africa.

Keywords: Adolescents; Cash transfers; Education; HIV; HIV prevention; South Africa; Young women.

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Figures

Fig. 1
Fig. 1
Prevalence of HIV, HSV-2 and prior pregnancy, by age at baseline among young women enrolled in HPTN 068, Agincourt, South Africa, March 2011–December 2012. a Among full sample (n = 2533) and b among sexually active (n = 693)
Fig. 2
Fig. 2
Frequency of combinations of risk factors at the individual-, household-, partner-, and school-level among young women enrolled in HPTN 068 at baseline in Agincourt, South Africa March 2011–December 2012
Fig. 3
Fig. 3
Prevalence of HIV and HSV-2 across each combination of risk factors at the individual-, household-, partner-, and school-level among young women enrolled in HPTN 068 at baseline in Agincourt, South Africa March 2011–December 2012
See this image and copyright information in PMC

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