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. 1989 Dec 18;259(1):199-201.
doi: 10.1016/0014-5793(89)81527-3.

Secretion of islet amyloid polypeptide in response to glucose

A Kanatsuka  1 , H Makino, H Ohsawa, Y Tokuyama, T Yamaguchi, S Yoshida, M Adachi
Affiliations
Free article

Secretion of islet amyloid polypeptide in response to glucose

A Kanatsuka et al. FEBS Lett. .
Free article

Abstract

The content of islet amyloid polypeptide (IAPP) in isolated rat pancreatic islets was determined by a radioimmunoassay. Reverse-phase high-performance liquid chromatography analysis revealed that a main peak of IAPP immunoreactivity in the extracts from the islets corresponded to a synthetic rat IAPP. Secretion of IAPP from the cells is regulated by the extracellular glucose concentration. Thus, IAPP may be a novel regulator for glucose homeostasis and changes in the secretion perhaps relate to insular amyloid deposits and impaired glucose tolerance in type 2 diabetes mellitus.

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