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. 2016 Feb 19:6:21312.
doi: 10.1038/srep21312.

Increased risk of hepatic complications in kidney transplantation with chronic virus hepatitis infection: A nationwide population-based cohort study

Tung-Min Yu  1   2 , Che-Chen Lin  3   4 , Kuo-Hsiung Shu  2 , Ya-Wen Chuang  2 , Shih-Ting Huang  2 , Cheng-Hsu Chen  2 , Ming-Ju Wu  2 , Mu-Chi Chung  2 , Chao-Hsiang Chang  3   5 , Chi-Yuan Li  3   6 , Chi-Jung Chung  7   8
Affiliations

Increased risk of hepatic complications in kidney transplantation with chronic virus hepatitis infection: A nationwide population-based cohort study

Tung-Min Yu et al. Sci Rep. .

Abstract

Data regarding the risk of various liver diseases among different hepatitis viruses in kidney transplantation have not yet been identified.We selected individuals with kidney transplantation (ICD-9-CM V420 or 996.81) from 2000-2009 from the catastrophic illness registry of National Health Insurance Research Database (NHIRD)as the study cohort. The two end-points in the study included overall death, and post-transplant occurrence of hepatic disease. After adjustment for other risk factors, the risk of mortality was increased in patients with HBV infection (N = 352) and with HCV infection (N = 275) compared to those with neither HBV nor HCV infection (N = 3485). In addition,renal transplant recipients with HBV alone,HCV alone, and both with HBV and HCVinfectionrespectively had an approximately 10-fold hazard ratio (HR) = 9.84, 95% confidence interval (CI): 4.61-21.0, 4-fold increased risk (HR = 4.40, 95% CI: 1.85-10.5)and 5-fold increased risk (HR = 4.63, 95% CI: 1.06-20.2)of hepatocellular carcinoma (HCC)compared to those with neither HBV nor HCV infection. Our findings showed a significant risk of de novo liver disease in recipients with hepatitis virus infection. Based on our findings, we reinforce the importance and impact of hepatitis virus in renal transplantation.

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Figures

Figure 1
Figure 1. Comparison of patient survival stratified by virus status.
Figure 2
Figure 2. Comparison of kidney graft survival stratified by virus status.
Figure 3
Figure 3
Cumulative incidence rates of subsequent hepatic diseases stratified by virus status: (A) overall hepatic diseases, (B) hepatocellular carcinoma, (C) liver cirrhosis, and (D) hepatic failure.
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References

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