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. 2016 Feb;11(2):1077-1080.
doi: 10.3892/ol.2015.4023. Epub 2015 Dec 10.

Hepatoid adenocarcinoma of the stomach: A case report of a rare type of gastric cancer

Zhihong Shen  1 , Xibo Liu  1 , Baochun Lu  1 , Minfeng Ye  1
Affiliations

Hepatoid adenocarcinoma of the stomach: A case report of a rare type of gastric cancer

Zhihong Shen et al. Oncol Lett. 2016 Feb.

Abstract

Hepatoid adenocarcinoma of the stomach (HAS) is a rare type of gastric cancer with an extremely poor prognosis. The current study reports a rare case of HAS, characterized by gastric cancer and infiltration of cancer cells into the left liver lobe, as well as lymphadenectasis. The expression of α-fetoprotein (AFP) was markedly increased in the tumor cells of the liver neoplasms. A gastric biopsy indicated highly, moderately and poorly differentiated papillary adenocarcinoma. The patient underwent two cycles of chemotherapy with oxaliplatin (130 mg; day 1) and capecitabine (2 mg, twice daily; days 1-14). At 7 weeks after the chemotherapy, an expanded gastrectomy and radical resection of left lung lobe were performed on the operable lesion. AFP expression was significantly decreased following the procedure. A literature review was also conducted by searching PubMed/Medline, indicating that surgery and chemotherapy may positively affect the outcomes of HAS patients.

Keywords: chemotherapy; gastric cancer; hepatoid adenocarcinoma of stomach; prognosis; α-fetoprotein.

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Figures

Figure 1.
Figure 1.
Imaging results. (A) Computed tomography imaging revealed a lesion in the left lobe of the liver prior to surgery. (B) Endoscopy identified a protruding lesion in the gastric antrum prior to chemotherapy.
Figure 2.
Figure 2.
Histochemical and immunostaining results. (A) Highly differentiated adenocarcinoma and small cellular atypia was identified in gastric samples (H&E staining; magnification, ×100). (B) Poorly differentiated adenocarcinoma was identified in hepatic samples; the tumor demonstrated an infiltrative growth pattern (H&E staining; magnification, ×100). (C) Poorly, moderately and highly differentiated hepatocellular carcinomas were identified in the liver (H&E staining; magnification, ×200). (D) Poorly differentiated adenocarcinoma was identified in the gastric sample, which exhibited hepatocyte-like differentiation and interstitial edema (H&E staining; magnification, ×200). (E) α-fetoprotein expression in hepatic samples (magnification, ×100). H&E, hematoxylin and eosin.
See this image and copyright information in PMC

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