Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 Mar 14;55(12):3858-60.
doi: 10.1002/anie.201511055. Epub 2016 Feb 19.

Accurate Lipophilicity (log P) Measurements Inform on Subtle Stereoelectronic Effects in Fluorine Chemistry

David O'Hagan  1 , Robert J Young  2
Affiliations
Comment

Accurate Lipophilicity (log P) Measurements Inform on Subtle Stereoelectronic Effects in Fluorine Chemistry

David O'Hagan et al. Angew Chem Int Ed Engl. .

Abstract

Polar exploration: Recently, Linclau and co-workers disclosed a straightforward (19)F-NMR method for determining the log P values of fluorocarbons. The method is particularly useful for most polar compounds and provides a quantitative way to rationalize the more subtle stereoelectronic consequences of fluorine introduction.

Keywords: NMR spectroscopy; fluorine; fluorocarbons; lipophilicity.

PubMed Disclaimer

Comment on

LinkOut - more resources