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. 2016 Apr:41:96-8.
doi: 10.1016/j.canep.2016.01.014. Epub 2016 Feb 16.

Human papillomavirus not detected in esophageal adenocarcinoma tumor specimens

Annika Antonsson  1 , Lani Knight  2 , David C Whiteman  2 ; Australian Cancer Study
Affiliations

Human papillomavirus not detected in esophageal adenocarcinoma tumor specimens

Annika Antonsson et al. Cancer Epidemiol. 2016 Apr.

Abstract

Background: Human papillomavirus (HPV) has been implicated as playing a causal role in Barrett's esophagus, the metaplastic precursor to esophageal adenocarcinomas (EAC) and gastro-esophageal junction adenocarcinomas (GEJACs). We evaluated the presence of HPV DNA in EACs and GEJACs.

Study design: We analyzed 241 histologically confirmed archived EAC and GEJAC tissue specimens from a population-based study in Australia. Samples were tested by PCR for DNA quality (β-globin) and for the presence of HPV DNA.

Results: DNA yield and quality was satisfactory in 97% (233/241; 201 EAC, 32 GEJAC). Each sample was tested three times for HPV DNA, but none of the 233 tumor specimens tested positive.

Conclusions: We found no evidence of HPV DNA in esophageal adenocarcinoma tumor cells. HPV is unlikely to cause EAC or GEJAC.

Keywords: Barrett’s esophagus; Esophageal adenocarcinoma; Gastro-esophageal junction adenocarcinoma; HPV DNA; Human papillomavirus.

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