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Review
. 2016 Mar;30(1):85-102.
doi: 10.1016/j.idc.2015.10.010.

Basic Genetics and Immunology of Candida Infections

Xiaowen Wang  1 , Frank L van de Veerdonk  2 , Mihai G Netea  3
Affiliations
Review

Basic Genetics and Immunology of Candida Infections

Xiaowen Wang et al. Infect Dis Clin North Am. 2016 Mar.

Abstract

Candida infections can cause superficial and invasive disease. Several essential mechanisms underlying the pathogenesis of these infections were known for some time, such as neutropenia predisposing to invasive disease, and CD4 lymphopenia causing increased susceptibility to mucosal candidiasis. However, the development of novel genetic screening techniques has led to several new insights in the genetics and immunology of candida infections. This article highlights novel insights in the pathogenesis of mucocutaneous and invasive candidiasis that have been identified in recent years.

Keywords: Candida; Candidiasis; Genetics; Immunology.

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