Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 May;61(5):1268-81.
doi: 10.1007/s10620-016-4045-1. Epub 2016 Feb 22.

Gut Microbiota of Nonalcoholic Fatty Liver Disease

Reham M Abdou  1 , Lixin Zhu  2   3 , Robert D Baker  2 , Susan S Baker  2
Affiliations
Review

Gut Microbiota of Nonalcoholic Fatty Liver Disease

Reham M Abdou et al. Dig Dis Sci. 2016 May.

Abstract

The prevalence of nonalcoholic fatty liver disease has been rapidly increasing worldwide. It has become a leading cause of liver transplantation. Accumulating evidence suggests a significant role for gut microbiota in its development and progression. Here we review the effect of gut microbiota on developing hepatic fatty infiltration and its progression. Current literature supports a possible role for gut microbiota in the development of liver steatosis, inflammation and fibrosis. We also review the literature on possible interventions for NAFLD that target the gut microbiota.

Keywords: Fibrosis; Inflammation; Microbiota and intestinal permeability; NAFLD; NASH; Steatosis.

PubMed Disclaimer

References

    1. Am J Clin Nutr. 2014 Mar;99(3):535-42 - PubMed
    1. J Gastroenterol Hepatol. 2014 Jun;29(6):1292-8 - PubMed
    1. Immunol Lett. 2003 Jan 22;85(2):85-95 - PubMed
    1. Clin Res Hepatol Gastroenterol. 2012 Dec;36(6):554-60 - PubMed
    1. J Pediatr Gastroenterol Nutr. 2012 Jan;54(1):90-6 - PubMed

Publication types

MeSH terms

LinkOut - more resources