Gut Microbiota of Nonalcoholic Fatty Liver Disease

Abstract

The prevalence of nonalcoholic fatty liver disease has been rapidly increasing worldwide. It has become a leading cause of liver transplantation. Accumulating evidence suggests a significant role for gut microbiota in its development and progression. Here we review the effect of gut microbiota on developing hepatic fatty infiltration and its progression. Current literature supports a possible role for gut microbiota in the development of liver steatosis, inflammation and fibrosis. We also review the literature on possible interventions for NAFLD that target the gut microbiota.

Keywords: Fibrosis; Inflammation; Microbiota and intestinal permeability; NAFLD; NASH; Steatosis.