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. 2016 May;37(5):307-20.
doi: 10.1016/j.revmed.2016.01.005. Epub 2016 Feb 16.

[Prevention of infections in adults and adolescents with systemic lupus erythematosus: Guidelines for the clinical practice based on the literature and expert opinion]

[Article in French]
A Mathian  1 , L Arnaud  2 , D Adoue  3 , C Agard  4 , B Bader-Meunier  5 , V Baudouin  6 , C Belizna  7 , B Bonnotte  8 , F Boumedine  9 , A Chaib  9 , M Chauchard  10 , L Chiche  11 , E Daugas  12 , A Ghali  7 , P Gobert  13 , G Gondran  14 , G Guettrot-Imbert  15 , E Hachulla  16 , M Hamidou  4 , J Haroche  2 , B Hervier  9 , A Hummel  17 , N Jourde-Chiche  18 , A-S Korganow  19 , T Kwon  6 , V Le Guern  20 , A Le Quellec  21 , N Limal  22 , N Magy-Bertrand  23 , P Marianetti-Guingel  24 , T Martin  19 , N Martin Silva  25 , O Meyer  26 , M Miyara  2 , S Morell-Dubois  16 , J Ninet  27 , J-L Pennaforte  24 , K Polomat  28 , J Pourrat  29 , V Queyrel  30 , I Raymond  31 , P Remy  32 , K Sacre  10 , J Sibilia  33 , J-F Viallard  31 , A Viau Brabant  24 , T Hanslik  34 , Z Amoura  2 ; le groupe France lupus érythémateux systémique réseau (FLEUR) et les centres de référence et de compétence des lupus et syndromes des antiphospholipides
Affiliations

[Prevention of infections in adults and adolescents with systemic lupus erythematosus: Guidelines for the clinical practice based on the literature and expert opinion]

[Article in French]
A Mathian et al. Rev Med Interne. 2016 May.

Abstract

Purpose: To develop French recommendations about the management of vaccinations, the screening of cervical cancer and the prevention of pneumocystis pneumonia in systemic lupus erythematosus (SLE).

Methods: Thirty-seven experts qualified in internal medicine, rheumatology, dermatology, nephrology and pediatrics have selected recommendations from a list of proposition based on available data from the literature. For each recommendation, the level of evidence and the level of agreement among the experts were specified.

Results: Inactivated vaccines do not cause significant harm in SLE patients. Experts recommend that lupus patient should receive vaccinations accordingly to the recommendations and the schedules for the general public. Pneumococcal vaccination is recommended for all SLE patients. Influenza vaccination is recommended for immunosuppressed SLE patients. Live attenuated vaccines should be avoided in immunosuppressed patients. Yet, recent works suggest that they can be considered in mildly immunosuppressed patients. Experts have recommended a cervical cytology every year for immunosuppressed patients. No consensus was obtained for the prevention of pneumocystis pneumonia.

Conclusion: These recommendations can be expected to improve clinical practice uniformity and, in the longer term, to optimize the management of SLE patients.

Keywords: Guidelines; Infection; Lupus systémique; Recommandations; Systemic lupus erythematosus; Vaccination.

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