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. 2016;21(3):257-66.
doi: 10.3109/1354750X.2015.1134663. Epub 2016 Feb 22.

Infant birth weight and third trimester maternal plasma markers of vascular integrity: the MIREC study

Premkumari Kumarathasan  1 , Renaud Vincent  2 , Agnieszka Bielecki  1 , Erica Blais  1 , Katrin Blank  1 , Dharani Das  1 , Subramanian Karthikeyan  2 , Sabit Cakmak  3 , Mandy Fisher  3 , Tye Arbuckle  3 , William Fraser  4
Affiliations

Infant birth weight and third trimester maternal plasma markers of vascular integrity: the MIREC study

Premkumari Kumarathasan et al. Biomarkers. 2016.

Abstract

Background: There is paucity of information on mechanisms constituting adverse birth outcomes. We assessed here the relationship between vascular integrity and adverse birth effects.

Methods and results: Third trimester maternal plasma (n = 144) from the Maternal-Infant Research on Environmental Chemicals Study (MIREC) was analysed for vascular, inflammatory and oxidative stress markers by HPLC-fluorescence, protein array and EIA method. Analysis of the <25th and >75th percentile birth weight subgroups revealed markers associated with birth weight (ETs, MMP-9, VEGF, and 8-isoPGF-2α) and gestational age (ET-1, MMP-2, and VEGF).

Conclusions: Mechanistic insights into adverse birth outcome pathways can be achieved by integrating information on multiple biomarkers, physiology using systems biology approach.

Keywords: Gestational age; infant birth weight; maternal plasma biomarkers; oxidative stress; vascular function.

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Figures

Figure 1.
Figure 1.
Distribution profiles for the n = 144 pregnancies. (A) Infant birth weight. (B) Gestational age. (C) Birth weight/gestational age. Black circles: subsample for current study (n = 144). Empty circles: Entire MIREC Cohort.
Figure 2.
Figure 2.
Heatmap and hierarchical clustering of correlation analysis results for all data. Color key/histogram indicates the strength of correlation (r values). Darker (red) shade indicates positive correlation. Lighter (yellow) shade indicates negative correlation.
Figure 3.
Figure 3.
Venn diagram of maternal factors dictating infant birth weight based on infant birth weight distribution data analysed by best subsets regression analyses. (A) All data. (B)  <25th percentile IBW. (C)  >75th percentile IBW.
Figure 4.
Figure 4.
Association of maternal biomarker profiles and (A) infant birth weight. (B) Gestational age.
Figure 5.
Figure 5.
Primary protein networks obtained through ingenuity pathway analysis (IPA) of the fold change of plasma markers in the identified sub groups versus the control group (25th–75th percentile). (A) Network 1 depicting pathways related to cardiovascular disease (<25th percentile) and (B) Network 2 depicting pathways related to inflammatory response (>75th percentile). Red: up-regulation; Green: down-regulation.
See this image and copyright information in PMC

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