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. 1989 Dec;86(24):9941-5.
doi: 10.1073/pnas.86.24.9941.

An altered v-raf is required in addition to v-myc in J3V1 virus for acceleration of murine plasmacytomagenesis

J Troppmair  1 , M Potter, J S Wax, U R Rapp
Affiliations

An altered v-raf is required in addition to v-myc in J3V1 virus for acceleration of murine plasmacytomagenesis

J Troppmair et al. Proc Natl Acad Sci U S A. 1989 Dec.

Abstract

We have isolated and molecularly cloned a highly pathogenic virus variant, J3V1, from murine plasmacytomas induced by a combination of pristane and the weakly transforming recombinant retrovirus J3. J3 virus is a derivative of the v-raf/v-myc-carrying J2 virus that was generated by a frameshifting deletion inactivating v-raf in J2. J3V1 contains an additional deletion of 334 base paris in gag, which restores the correct reading frame for v-raf and results in the expression of a p57 gag-raf fusion protein. Reactivation of v-raf in J3 is required for efficient plasmacytoma acceleration in pristane-conditioned BALB/cAn mice.

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References

    1. J Virol. 1985 Jul;55(1):23-33 - PubMed
    1. J Exp Med. 1984 Jun 1;159(6):1762-77 - PubMed
    1. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6868-72 - PubMed
    1. Semin Oncol. 1986 Sep;13(3):275-81 - PubMed
    1. Mol Cell Biol. 1986 Mar;6(3):870-7 - PubMed

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