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. 2016 Feb 22;11(2):e0149216.
doi: 10.1371/journal.pone.0149216. eCollection 2016.

Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds

Denis V Axenov-Gribanov, Irina V Voytsekhovskaya  1 , Bogdan T Tokovenko  2 , Eugeniy S Protasov  1 , Stanislav V Gamaiunov  1 , Yuriy V Rebets  2 , Andriy N Luzhetskyy  2   3 , Maxim A Timofeyev  1
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Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds

Denis V Axenov-Gribanov et al. PLoS One. .

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Abstract

Actinobacteria isolated from unstudied ecosystems are one of the most interesting and promising sources of novel biologically active compounds. Cave ecosystems are unusual and rarely studied. Here, we report the isolation and characterization of ten new actinobacteria strains isolated from an ancient underground lake and moonmilk speleothem from the biggest conglomeratic karstic cave in Siberia with a focus on the biological activity of the obtained strains and the metabolite dereplication of one active strain. Streptomyces genera isolates from moonmilk speleothem demonstrated antibacterial and antifungal activities. Some of the strains were able to inhibit the growth of pathogenic Candida albicans.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Phylogenetic tree of actinobacteria isolates based on the 16S rRNA gene sequences.
Fig 2
Fig 2. Structure of Cyclodysidin D and Chaxalactin B and their identification in extract of Streptomyces sp. IB 2014/I/78-8.
See this image and copyright information in PMC

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