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Multicenter Study
. 2016 Jun;51(6):786-92.
doi: 10.1038/bmt.2016.20. Epub 2016 Feb 22.

Hematopoietic stem cell transplantation in Europe 2014: more than 40 000 transplants annually

J R Passweg  1 , H Baldomero  1 , P Bader  2 , C Bonini  3 , S Cesaro  4 , P Dreger  5 , R F Duarte  6 , C Dufour  7 , J Kuball  8 , D Farge-Bancel  9 , A Gennery  10 , N Kröger  11 , F Lanza  12 , A Nagler  13 , A Sureda  6 , M Mohty  14
Affiliations
Multicenter Study

Hematopoietic stem cell transplantation in Europe 2014: more than 40 000 transplants annually

J R Passweg et al. Bone Marrow Transplant. 2016 Jun.

Abstract

A record number of 40 829 hematopoietic stem cell transplantation (HSCT) in 36 469 patients (15 765 allogeneic (43%), 20 704 autologous (57%)) were reported by 656 centers in 47 countries to the 2014 survey. Trends include: continued growth in transplant activity, more so in Eastern European countries than in the west; a continued increase in the use of haploidentical family donors (by 25%) and slower growth for unrelated donor HSCT. The use of cord blood as a stem cell source has decreased again in 2014. Main indications for HSCT were leukemias: 11 853 (33%; 96% allogeneic); lymphoid neoplasias; 20 802 (57%; 11% allogeneic); solid tumors; 1458 (4%; 3% allogeneic) and non-malignant disorders; 2203 (6%; 88% allogeneic). Changes in transplant activity include more allogeneic HSCT for AML in CR1, myeloproliferative neoplasm (MPN) and aplastic anemia and decreasing use in CLL; and more autologous HSCT for plasma cell disorders and in particular for amyloidosis. In addition, data on numbers of teams doing alternative donor transplants, allogeneic after autologous HSCT, autologous cord blood transplants are presented.

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Figures

Figure 1
Figure 1
Relative proportions of indications for an HSCT in Europe in 2014. (a) Proportions of disease indications for an allogeneic HSCT in Europe in 2014. (b) Proportions of disease indications for an autologous HSCT in Europe in 2014.
Figure 2
Figure 2
Transplant rates in Europe (=total number of HSCT per 10 million inhabitants) by participating country in 2014. (a) Allogeneic transplant rates per 10 million population in 2014. (b) Autologous transplant rates per 10 million population in 2014.
Figure 3
Figure 3
Numbers of HSCT and teams by transplant and donor type 1990–2014. (a) Absolute numbers of sibling, haploidentical, cord blood and unrelated donors HSCT in Europe 1990–2014. (b) Number of teams by choice of donor in Europe 1990–2014.
Figure 4
Figure 4
Main indication for allogeneic HSCT after a previous autologous HSCT in Europe since 2004.
Figure 5
Figure 5
Percentage increase in HSCT activity between the years 2004 and 2014 in countries reporting >100 HSCT in 2014. (a) Increase in allogeneic HSCT. (b) Increase in autologous HSCT.
See this image and copyright information in PMC

References

    1. Copelan EA. Hematopoietic stem-cell transplantation. N Engl J Med 2006; 354: 1813–1826. - PubMed
    1. Appelbaum FR. Hematopoietic-cell transplantation at 50. N Engl J Med 2007; 357: 1472–1475. - PubMed
    1. Ljungman P, Bregni M, Brune M, Cornelissen J, deWitte T, Dini G et al. European Group for Blood and Marrow. Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe 2009. Bone Marrow Transplant 2010; 45: 219–234. - PubMed
    1. Gratwohl A, Baldomero H, Aljurf M, Pasquini MC, Bouzas LF, Yoshimi et al. Hematopoietic stem cell transplantation: a global perspective. JAMA 2010; 303: 1617–1624. - PMC - PubMed
    1. Alois G, Marcelo CP, Mahmoud A, Yoshiko A, Helen B, Lydia F et al. One million haemopoietic stem-cell transplants: a retrospective observational study. Lancet Haematol 2015; 2: e91–e100. - PubMed

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