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. 2016 May;13(2):128-36.
doi: 10.1177/1479972316632005. Epub 2016 Feb 22.

Validation of a Spanish version of the Leicester Cough Questionnaire in non-cystic fibrosis bronchiectasis

Gerard Muñoz  1 , Maria Buxó  2 , Javier de Gracia  3 , Casilda Olveira  4 , Miguel Angel Martinez-Garcia  5 , Rosa Giron  6 , Eva Polverino  7 , Antonio Alvarez  3 , Surinder S Birring  8 , Montserrat Vendrell  9
Affiliations

Validation of a Spanish version of the Leicester Cough Questionnaire in non-cystic fibrosis bronchiectasis

Gerard Muñoz et al. Chron Respir Dis. 2016 May.

Abstract

The Leicester Cough Questionnaire (LCQ) has been validated in non-cystic fibrosis bronchiectasis (NCFBC). The present study aimed to create and validate a Spanish version of the LCQ (LCQ-Sp) in NCFBC. The LCQ-Sp was developed following a standardized protocol. For reliability, we assessed internal consistency and the change in score over a 15-day period in stable state. For responsiveness, we assessed the change in scores between visit 1 and the first exacerbation. For validity, we evaluated convergent validity through correlation with the Saint George's Respiratory Questionnaire (SGRQ) and discriminant validity. Two hundred fifty-nine patients (118 mild bronchiectasis, 90 moderate bronchiectasis and 47 severe bronchiectasis) were included. Internal consistency was high for the total scoring and good for the different domains (Cronbach's α: 0.86-0.91). The test-retest reliability shows an intraclass correlation coefficient of 0.87 for the total score. The mean LCQ-Sp score at visit 1 decreased at the beginning of an exacerbation (15.13 ± 4.06 vs. 12.24 ± 4.64; p < 0.001). The correlation between LCQ-Sp and SGRQ scores was -0.66 (p < 0.01). The differences in the LCQ-Sp total score between the different groups of severity were significant (p < 0.001). The LCQ-Sp discriminates disease severity, is responsive to change when faced with exacerbations and is reliable for use in bronchiectasis.

Keywords: Bronchiectasis; cough; patient-reported outcome; quality of life; questionnaire.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Flow chart of the study. LCQ-Sp: Spanish version of the Leicester Cough Questionnaire; SGRQ: Saint Georges Respiratory Questionnaire; mMRC: modified Medical Research Council dyspnoea scale.
Figure 2.
Figure 2.
Bland–Altman plot of LCQ-Sp total score repeated over 15 days in 199 patients with stable bronchiectasis. —: Mean difference between the two scores (−0.10); ------: 95% limits of agreement (−4.8 to 4.6). LCQ: Leicester Cough Questionnaire; LCQ-Sp: Spanish version of the LCQ.
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