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. 2016 May;13(2):128-36.
doi: 10.1177/1479972316632005. Epub 2016 Feb 22.

Validation of a Spanish version of the Leicester Cough Questionnaire in non-cystic fibrosis bronchiectasis

Gerard Muñoz  1 , Maria Buxó  2 , Javier de Gracia  3 , Casilda Olveira  4 , Miguel Angel Martinez-Garcia  5 , Rosa Giron  6 , Eva Polverino  7 , Antonio Alvarez  3 , Surinder S Birring  8 , Montserrat Vendrell  9
Affiliations

Validation of a Spanish version of the Leicester Cough Questionnaire in non-cystic fibrosis bronchiectasis

Gerard Muñoz et al. Chron Respir Dis. 2016 May.

Abstract

The Leicester Cough Questionnaire (LCQ) has been validated in non-cystic fibrosis bronchiectasis (NCFBC). The present study aimed to create and validate a Spanish version of the LCQ (LCQ-Sp) in NCFBC. The LCQ-Sp was developed following a standardized protocol. For reliability, we assessed internal consistency and the change in score over a 15-day period in stable state. For responsiveness, we assessed the change in scores between visit 1 and the first exacerbation. For validity, we evaluated convergent validity through correlation with the Saint George's Respiratory Questionnaire (SGRQ) and discriminant validity. Two hundred fifty-nine patients (118 mild bronchiectasis, 90 moderate bronchiectasis and 47 severe bronchiectasis) were included. Internal consistency was high for the total scoring and good for the different domains (Cronbach's α: 0.86-0.91). The test-retest reliability shows an intraclass correlation coefficient of 0.87 for the total score. The mean LCQ-Sp score at visit 1 decreased at the beginning of an exacerbation (15.13 ± 4.06 vs. 12.24 ± 4.64; p < 0.001). The correlation between LCQ-Sp and SGRQ scores was -0.66 (p < 0.01). The differences in the LCQ-Sp total score between the different groups of severity were significant (p < 0.001). The LCQ-Sp discriminates disease severity, is responsive to change when faced with exacerbations and is reliable for use in bronchiectasis.

Keywords: Bronchiectasis; cough; patient-reported outcome; quality of life; questionnaire.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Flow chart of the study. LCQ-Sp: Spanish version of the Leicester Cough Questionnaire; SGRQ: Saint Georges Respiratory Questionnaire; mMRC: modified Medical Research Council dyspnoea scale.
Figure 2.
Figure 2.
Bland–Altman plot of LCQ-Sp total score repeated over 15 days in 199 patients with stable bronchiectasis. —: Mean difference between the two scores (−0.10); ------: 95% limits of agreement (−4.8 to 4.6). LCQ: Leicester Cough Questionnaire; LCQ-Sp: Spanish version of the LCQ.
See this image and copyright information in PMC

References

    1. Vendrell M, de Gracia J, Olveira C, et al. Diagnosis and treatment of bronchiectasis. Spanish society of pneumology and thoracic surgery. Arch Bronconeumol 2008; 44: 629–640. - PubMed
    1. Murray MP, Govan JRW, Doherty CJ, et al. A randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis. Am J Respir Crit Care Med 2011; 183: 491–499. - PubMed
    1. Jones PW, Quirk FH, Baveystock CM, et al. A self-completed measure for chronic airflow limitation: the St George’s respiratory questionnaire. Am Rev Respir Dis 1992; 145: 1321–1327. - PubMed
    1. Wilson CB, Paul WJ, O’leary CJ, et al. Validation of the St. George’s respiratory questionnaire in bronchiectasis. Am J Respir Crit Care Med 1997; 156: 536–541. - PubMed
    1. Birring SS, Prudon B, Carr AJ, et al. Development of a symptom specific health status measure for patients with chronic cough: leicester cough questionnaire (LCQ). Thorax 2003; 58: 339–343. - PMC - PubMed

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