Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases

Dean D Metcalfe¹, Ruby Pawankar², Steven J Ackerman³, Cem Akin⁴, Frederic Clayton⁵, Franco H Falcone⁶, Gerald J Gleich⁷, Anne-Marie Irani⁸, Mats W Johansson⁹, Amy D Klion¹⁰, Kristin M Leiferman¹¹, Francesca Levi-Schaffer¹², Gunnar Nilsson¹³, Yoshimichi Okayama¹⁴, Calman Prussin¹, John T Schroeder¹⁵, Lawrence B Schwartz¹⁶, Hans-Uwe Simon¹⁷, Andrew F Walls¹⁸, Massimo Triggiani¹⁹

Affiliations

¹ Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 USA.
² Division of Allergy, Department of Pediatrics, Nippon Medical School, Tokyo, Japan.
³ Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois, Chicago, IL USA.
⁴ Harvard Medical School, Brigham and Women's Hospital, Boston, MA USA.
⁵ Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT USA.
⁶ The School of Pharmacy, University of Nottingham, Nottingham, United Kingdom.
⁷ Department of Dermatology, University of Utah, School of Medicine, Salt Lake City, UT USA.
⁸ Virginia Commonwealth University, Children's Hospital of Richmond, Richmond, VA USA.
⁹ Department of Biomolecular Chemistry, University of Wisconsin, Madison, WI USA.
¹⁰ Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD USA.
¹¹ University of Utah, Salt Lake City, UT USA.
¹² The Hebrew University of Jerusalem, Jerusalem, Israel.
¹³ Clinical Immunology and Allergy, Department of Medicine, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
¹⁴ Allergy and Immunology Group, Research Institute of Medical Science, Nihon University Graduate School of Medicine, Tokyo, Japan.
¹⁵ Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA.
¹⁶ Virginia Commonwealth University, Richmond, VA USA.
¹⁷ University of Bern, Institute of Pharmacology, Bern, Switzerland.
¹⁸ Southampton General Hospital, Immunopharmacology Group, Southampton, Hampshire UK.
¹⁹ Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy.

PMID: 26904159
PMCID: PMC4751725
DOI: 10.1186/s40413-016-0094-3

Review

Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases

Dean D Metcalfe et al. World Allergy Organ J. 2016.

. 2016 Feb 11:9:7.

doi: 10.1186/s40413-016-0094-3. eCollection 2016.

Authors

Affiliations

¹ Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 USA.
² Division of Allergy, Department of Pediatrics, Nippon Medical School, Tokyo, Japan.
³ Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois, Chicago, IL USA.
⁴ Harvard Medical School, Brigham and Women's Hospital, Boston, MA USA.
⁵ Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT USA.
⁶ The School of Pharmacy, University of Nottingham, Nottingham, United Kingdom.
⁷ Department of Dermatology, University of Utah, School of Medicine, Salt Lake City, UT USA.
⁸ Virginia Commonwealth University, Children's Hospital of Richmond, Richmond, VA USA.
⁹ Department of Biomolecular Chemistry, University of Wisconsin, Madison, WI USA.
¹⁰ Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD USA.
¹¹ University of Utah, Salt Lake City, UT USA.
¹² The Hebrew University of Jerusalem, Jerusalem, Israel.
¹³ Clinical Immunology and Allergy, Department of Medicine, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
¹⁴ Allergy and Immunology Group, Research Institute of Medical Science, Nihon University Graduate School of Medicine, Tokyo, Japan.
¹⁵ Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA.
¹⁶ Virginia Commonwealth University, Richmond, VA USA.
¹⁷ University of Bern, Institute of Pharmacology, Bern, Switzerland.
¹⁸ Southampton General Hospital, Immunopharmacology Group, Southampton, Hampshire UK.
¹⁹ Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy.

PMID: 26904159
PMCID: PMC4751725
DOI: 10.1186/s40413-016-0094-3

Abstract

Biomarkers of disease activity have come into wide use in the study of mechanisms of human disease and in clinical medicine to both diagnose and predict disease course; as well as to monitor response to therapeutic intervention. Here we review biomarkers of the involvement of mast cells, basophils, and eosinophils in human allergic inflammation. Included are surface markers of cell activation as well as specific products of these inflammatory cells that implicate specific cell types in the inflammatory process and are of possible value in clinical research as well as within decisions made in the practice of allergy-immunology.

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References

1. Johansson MW. Activation states of blood eosinophils in asthma. Clin Exp Allergy. 2014;44(4):482–98. doi: 10.1111/cea.12292. - DOI - PMC - PubMed
1. Johansson MW, Mosher DF. Integrin activation states and eosinophil recruitment in asthma. Front Pharmacol. 2013;4:33. doi: 10.3389/fphar.2013.00033. - DOI - PMC - PubMed
1. Rosenberg HF, Dyer KD, Foster PS. Eosinophils: changing perspectives in health and disease. Nat Rev Immunol. 2013;13(1):9–22. doi: 10.1038/nri3341. - DOI - PMC - PubMed
1. Driss V, Legrand F, Capron M. Eosinophils receptor profile. In: Lee J, Rosenberg HF, editors. Eosinophils in health and disease. 1. Waltham: Elsevier/Academic Press; 2013. pp. 30–8.
1. Johnsson M, Bove M, Bergquist H, Olsson M, Fornwall S, Hassel K, et al. Distinctive blood eosinophilic phenotypes and cytokine patterns in eosinophilic esophagitis, inflammatory bowel disease and airway allergy. J Innate Immun. 2011;3(6):594–604. doi: 10.1159/000331326. - DOI - PubMed

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Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases

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Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases

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