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. 2015 Dec 12:10:1-5.
doi: 10.1016/j.nmni.2015.11.013. eCollection 2016 Mar.

Distribution of innate efflux-mediated aminoglycoside resistance among different Achromobacter species

J Bador  1 , C Neuwirth  1 , P Liszczynski  1 , M-C Mézier  1 , M Chrétiennot  1 , E Grenot  1 , A Chapuis  1 , C de Curraize  1 , L Amoureux  1
Affiliations

Distribution of innate efflux-mediated aminoglycoside resistance among different Achromobacter species

J Bador et al. New Microbes New Infect. .

Abstract

Achromobacter spp. are emerging respiratory pathogens in cystic fibrosis patients. Since 2013 the genus Achromobacter includes 15 species for which innate antibiotic resistance is unknown. Previously the AxyXY-OprZ efflux system has been described to confer aminoglycoside (AG) resistance in A. xylosoxidans. Nevertheless, some Achromobacter spp. strains are susceptible to AG. This study including 49 Achromobacter isolates reveals that AG resistance is correlated with different Achromobacter spp. It is noteworthy that the axyXY-oprZ operon is detected only in AG-resistant species, including the most frequently encountered in cystic fibrosis patients: A. xylosoxidans, A. ruhlandii, A. dolens and A. insuavis.

Keywords: Achromobacter; AxyXY-OprZ; aminoglycoside resistance; cystic fibrosis; nrdA; selection pressure.

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Figures

Fig. 1
Fig. 1
ACH-CF-583 nrdA sequence alignment with its closest match (genogroup 19) in Achromobacter PubMLST database. Query: ACH-CF-583; Ref: closest match in database.
Fig. 2
Fig. 2
Neighbour-joining dendrogram based on nrdA sequence. Numbers at nodes indicate bootstrap values. Scale bar indicates number of substitutions per site. AG-resistant (AG-R) isolates are in upper box; AG-susceptible (AG-S) isolates are in boxes ‘cluster 1’ and ‘cluster 2.’ AG resistance was not determined for the LMG strains.
See this image and copyright information in PMC

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