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Review
. 2016:2016:4175293.
doi: 10.1155/2016/4175293. Epub 2016 Jan 20.

The Role of Current Techniques and Concepts in Peripheral Nerve Repair

K S Houschyar  1 , A Momeni  2 , M N Pyles  2 , J Y Cha  3 , Z N Maan  2 , D Duscher  4 , O S Jew  2 , F Siemers  5 , J van Schoonhoven  6
Affiliations
Review

The Role of Current Techniques and Concepts in Peripheral Nerve Repair

K S Houschyar et al. Plast Surg Int. 2016.

Abstract

Patients with peripheral nerve injuries, especially severe injury, often face poor nerve regeneration and incomplete functional recovery, even after surgical nerve repair. This review summarizes treatment options of peripheral nerve injuries with current techniques and concepts and reviews developments in research and clinical application of these therapies.

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Figures

Figure 1
Figure 1
(a) In the PNS, support cells aid neuronal regeneration. Proliferating Schwann cells, macrophages, and monocytes work together to remove myelin debris, release neurotrophins, and lead axons toward their synaptic targets, resulting in restored neuronal function. (b) In the CNS, however, the few neurons that survive axotomy attempt regeneration and subsequently meet an impenetrable glial scar composed myelin and cellular debris, as well as astrocytes, oligodendrocytes, and microglia. Fibroblasts, monocytes, and macrophages may also be present in the glial scar. Consequently, regenerating neurons in the spinal cord are blocked from reaching their synaptic target.
Figure 2
Figure 2
Picture showing a vein conduit used to bridge traumatic nerve laceration.
See this image and copyright information in PMC

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