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Case Reports
. 2016 Feb;5(1):72-8.
doi: 10.3978/j.issn.2304-3881.2015.06.09.

Carcinosarcoma of the bile duct: a case report and review of literature

Ser Yee Lee  1 , Jinru Shia  1 , T Peter Kingham  1 , William R Jarnagin  1
Affiliations
Case Reports

Carcinosarcoma of the bile duct: a case report and review of literature

Ser Yee Lee et al. Hepatobiliary Surg Nutr. 2016 Feb.

Abstract

Carcinosarcomas of the bile ducts are very rare tumors consisting of both epithelial and mesenchymal elements. We report a case of bile duct carcinosarcoma and its clinical, radiological and pathological features and a brief review on this rare condition.

Keywords: Carcinosarcoma; bile duct; sarcomatoid carcinoma.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Computed tomography cross-sectional and coronal images. White arrows illustrate the hilar location and the intraductal papillary—like features of the bile duct carcinosarcoma distending the biliary confluence and causing proximal intrahepatic biliary dilatation.
Figure 2
Figure 2
Gross specimen. Arrows illustrate the areas of mural invasion involving the right hepatic duct wall near the resection margins when the tumor specimen was bivalved.
Figure 3
Figure 3
Histological features illustrating the mixed components of the tumor. (A) Both the exophytic and morally invasive components contained prominent sarcomatoid elements, in the form of spindle and pleomorphic tumor cells with prominent mitotic activity; (B) minor component of the tumor showed osteogenic differentiation with formation of malignant osteoid; (C) the carcinoma component, constituting about 10% of the entire tumor, had morphological features characteristic of biliary adenocarcinoma with tumor cells being cuboidal and the overall architectural pattern being papillary; (D) the underlying bile duct epithelium showed foci of low and high grade dysplasia. Hematoxylin and Eosin stain. Magnification: (A-C) is 100× and (D) is 40×.
See this image and copyright information in PMC

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