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. 1989 Dec;13(6):841-4.
doi: 10.1111/j.1530-0277.1989.tb00434.x.

Xanthine oxidase status in ethanol-intoxicated rat liver

A Abbondanza  1 , M G Battelli, M Soffritti, C Cessi
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Xanthine oxidase status in ethanol-intoxicated rat liver

A Abbondanza et al. Alcohol Clin Exp Res. 1989 Dec.

Abstract

The status of xanthine oxidase in ethanol-induced liver injury has been investigated in the rat, by acute and chronic ethanol treatments. A 38% increase of the enzyme O-form was observed after repeated ethanol administration. Chronic intoxication caused a significant decrease of total xanthine oxidase activity after both prolonged ethanol feeding and life span ethanol ingestion. The intermediate D/O-form of xanthine oxidase (that can act either as an oxidase or as a dehydrogenase, being able to react with O2 as well as with NAD+ as electron acceptor) increased 5.5-fold after prolonged ethanol feeding.

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