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Meta-Analysis
. 2016 Feb;25(2):231-8.
doi: 10.1158/1055-9965.EPI-15-0833.

The Breast-Thyroid Cancer Link: A Systematic Review and Meta-analysis

Sarah M Nielsen  1 , Michael G White  2 , Susan Hong  3 , Briseis Aschebrook-Kilfoy  4 , Edwin L Kaplan  2 , Peter Angelos  2 , Swati A Kulkarni  5 , Olufunmilayo I Olopade  1 , Raymon H Grogan  6
Affiliations
Meta-Analysis

The Breast-Thyroid Cancer Link: A Systematic Review and Meta-analysis

Sarah M Nielsen et al. Cancer Epidemiol Biomarkers Prev. 2016 Feb.

Abstract

Rates of thyroid cancer in women with a history of breast cancer are higher than expected. Similarly, rates of breast cancer in those with a history of thyroid cancer are increased. Explanations for these associations include detection bias, shared hormonal risk factors, treatment effect, and genetic susceptibility. With increasing numbers of breast and thyroid cancer survivors, clinicians should be particularly cognizant of this association. Here, we perform a systematic review and meta-analysis of the literature utilizing PubMed and Scopus search engines to identify all publications studying the incidence of breast cancer as a secondary malignancy following a diagnosis of thyroid cancer or thyroid cancer following a diagnosis of breast cancer. This demonstrated an increased risk of thyroid cancer as a secondary malignancy following breast cancer [OR = 1.55; 95% confidence interval (CI), 1.44-1.67] and an increased risk of breast cancer as a secondary malignancy following thyroid cancer (OR = 1.18; 95% CI, 1.09-1.26). There is a clear increase in the odds of developing either thyroid or breast cancer as a secondary malignancy after diagnosis with the other. Here, we review this association and current hypothesis as to the cause of this correlation.

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Conflict of interest statement

Conflict of Interest: The authors have not significant financial interests to disclose.

Figures

Figure 1
Figure 1
Summary of systematic review performed querying both Scopus and PubMed databases
Figure 2
Figure 2
Odds ratio of developing thyroid cancer as a secondary malignancy following diagnosis and treatment for breast cancer. Odds ratio on meta-analysis is 1.55 (95% CI [1.44,1.67])
Figure 3
Figure 3
Odds ratio of developing breast cancer as a secondary malignancy following diagnosis and treatment for thyroid cancer. Odds ratio on meta-analysis is 1.18 (95% CI [1.09,1.26])
See this image and copyright information in PMC

References

    1. Travis LB, Demark Waefried W, Allan JM, Wood ME, Ng AK. Aetiology, genetics and prevention of secondary neoplasms in adult cancer survivors. Nat Rev Clin Oncol. 2013;10:289–301. - PubMed
    1. Li CI, Rossing MA, Voigt LF, Daling JR. Multiple primary breast and thyroid cancers: role of age at diagnosis and cancer treatments (United States) Cancer causes & control: CCC. 2000;11:805–11. - PubMed
    1. Ronckers CM, McCarron P, Ron E. Thyroid cancer and multiple primary tumors in the SEER cancer registries. International journal of cancer Journal international du cancer. 2005;117:281–8. - PubMed
    1. Sandeep TC, Strachan MW, Reynolds RM, Brewster DH, Scelo G, Pukkala E, et al. Second primary cancers in thyroid cancer patients: a multinational record linkage study. The Journal of clinical endocrinology and metabolism. 2006;91:1819–25. - PubMed
    1. Subramanian S, Goldstein DP, Parlea L, Thabane L, Ezzat S, Ibrahim-Zada I, et al. Second primary malignancy risk in thyroid cancer survivors: a systematic review and meta-analysis. Thyroid: official journal of the American Thyroid Association. 2007;17:1277–88. - PubMed

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